Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa ledeb., on transplantable rodent tumors.
スポンサーリンク
概要
- 論文の詳細を見る
The effect of agrimoniin, a tannin contained in <I>Agrimonia pilosa</I> LEDEB., on ascites type and solid type rodent tumors was investigated. When agrimoniin was intraperitoneally (i.p.) administered at dosages over 10 mg/kg before or after the MM2 cell i.p. inoculation, this tannin almost completely rejected the tumor growth in the mice. This tannin prolonged the life span of mice bearing MM2 or cured by the intravenous or per oral pre or postmedication. Agrimoniin also inhibited the growth of MH1 34 and Meth-A solid type tumors. Agrimoniin showed strong cytotoxicity on MM2 cells in vitro, but the activity was diminished to about 4% of the initial activity by the addition of fetal calf serum to the culture. On the other hand, i.p. injection of agrimoniin increased the number of peripheral white blood cells and the ratio of monocytes. On the 4th day after the i.p. injection of the tannin, cytotoxic adherent peritoneal exudate cells were also increased. The spleen of the mice was enlarged, and the spleen cells possessed the capacity to take up <SUP>3</SUP>H-thymidine. Agrimoniin showed weak direct migration activity against spleen cells from non-treated mice. These results indicate that agrimoniin is a potent antitumor tannin and suggest that the antitumor effect may be due to this tannin enhancing the immune response of the host animals through the actions on tumor cells and some immunocytes.
- 公益社団法人 日本薬理学会の論文
著者
-
KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
-
Miyamoto Kenichi
Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie
-
KISHI Nobuharu
Department of Pharmacology, Hokuriku University School of Pharmacy
関連論文
- Methyl-CpG binding protein 2 gene (MECP2) variations in Japanese patients with Rett syndrome : pathological mutations and polymorphisms
- Genetic Background of Primary Iron Overload Syndromes in Japan
- Convenient synthetic method for 3-(3-substituted indol-2-yl)quinoxalin-2- ones as VEGF inhibitor
- Synthesis of a Capillarisin Sulfur-Analogue Possessing Aldose Reductase Inhibitory Activity by Selective Isopropylation
- Enhancement of Endothelial Nitric Oxide Production by Chenodeoxycholic Acids in Patients with Hepatobiliary Diseases
- Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol
- Selective drug delivery to bone using acidic oligopeptides
- Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure
- Insulin Signaling in Adipocytes Differentiated from Mouse Stromal MC3T3-G2/PA6 Cells(Biochemistry)
- Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity
- Reversal of P-Glycoprotein-Dependent Resistance to Vinblastine by Newly Synthesized Bisbenzylisoquinoline Alkaloids in Mouse Leukemia P388 Cells(Pharmacology)
- COMPARATIVE STUDIES ON THE COMBINED CYTOTOXIC EFFECT OF FORSKOLIN WITH MITOMYCIN C AND RESPONSIVENESS TO FORSKOLIN IN RAT ASCITES HEPATOMA AH66 CELLS AND AH66F CELLS
- HISTOLOGICAL STUDIES ON DEVELOPING CHICK EMBRYOS TREATED WITH AMINOGUANIDINE SULFATE
- EFFECT OF MITOMYCIN C ON THE ACTIVATION OF ADENYLATE CYCLASE IN RAT ASCITES HEPATOMA AH130 CELLS
- EFFECTS OF LOCAL ANESTHETICS, TETRODOTOXIN, ACONITINE AND VERAPAMIL ON THE MECHANORECEPTORS OF ISOLATED FROG HEART
- RECORDING OF PULMONARY AFFERENT ACTIVITIES FROM RECEPTORS IN THE PERFUSED LUNG PREPARATION OF BULLFROG AND EFFECTS OF DRUGS ON THE AFFERENT ACTIVITIES
- EFFECTS OF LOCAL ANESTHETICS ON THE PULMONARY MECHANORECEPTORS OF THE PERFUSED FROG LUNG
- Molecular Dynamics Simulation of a Collapsing Bubble
- ENHANCEMENT OF MITOMYCIN C UPTAKE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA
- Clustering analysis of Keishibukuryogan formulas by use of self-organizing maps
- Self Assembled Growth of Nano Particulate Porous ZnO Thin Film Modified by 2,9,16,23-Tetrasulfophthalocyanatozinc(II) by One-Step Electrodeposition
- THE ACTION OF MITOMYCIN C ON THE INDUCTION OF CYCLIC AMP PHOSPHODIESTERASE AND THE DEVELOPMENT OF DESENSITIZATION OF ADENYLATE CYCLASE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA AH130 CELLS
- RELATIONSHIP BETWEEN ENHANCEMENT OF CYTOTOXIC EFFECT OF MITOMYCIN C AND INCREASE OF INTRACELLULAR CYCLIC ADENOSINE 3' : 5'-MONOphoSPHATE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA CELLS
- EFFECT OF β-ADRENERGIC STIMULANTS ON CYTOTOXICITY OF MITOMYCIN C IN HeLa CELLS
- Initial Characterization of a Fibroblast-loaded Porous Elastin Film Reconstituted by a Novel Crosslinker, Dode-DSP
- Multiform Combination Effects of Smooth Muscle Relaxants with Antitumor Agents in Rat Ascites Hepatoma AH66 Cells
- Comparative Studies on Antitumor Activity of Klebsiella 03 Lipopolysaccharide and Its Polysaccharide Fraction in Mice
- Insulin signaling in adipocytes differentiated from mouse stromal MC3T3-G2/PA6 cells
- Increase of sensitivity and uptake of vinblastine by reserpine in rat ascites hepatoma.
- Structure-activity relationship in N3-alkyl-xanthine derivatives.
- Studies on responsiveness of hepatoma cells to catecholamines. III Difference between the receptor-adenylate cyclase regulating systems in AH130 cells and cultured normal rat liver cells.
- Antitumor activity of methanol extract from roots of Agrimonia pilosa Ledeb.
- Enhancement of the cytotoxic effect of mitomycin C by .BETA.-adrenergic stimulants in rat ascites hepatoma AH130 cells.
- Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa ledeb., on transplantable rodent tumors.
- Studies on responsiveness of hepatoma cells to catecholamines. I. Lack of .BETA.-adrenergic responsiveness in rat ascites hepatoma AH13 cells.
- Studies on responsiveness of hepatoma cells to catecholamines. IV Lack of adrenergic activation of phosphorylase in rat ascites hepatoma cells.
- Studies on responsiveness of hepatoma cells to catecholamines. II. Comparison of .BETA.-adrenergic responsiveness of rat ascites hepatoma cells with cultured normal rat liver cells.
- In vivo effects of drugs that act on the autonomic nervous system on the rat urinary bladder contraction accompanying micturition.
- The effects of tetrodotoxin, papaverine and verapamil on the increase in the rate of spontaneous afferent discharges induced by local anesthetics from the pulmonary mechanoreceptors of the bullfrog.
- Antitumor activity of Klebsiella 03 lipopolysaccharide in mice.
- The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats.
- Combined cytotoxic effect of isoproterenol with alkylating agents in HeLa cells.
- The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog.