EFFECTS OF LOCAL ANESTHETICS, TETRODOTOXIN, ACONITINE AND VERAPAMIL ON THE MECHANORECEPTORS OF ISOLATED FROG HEART
スポンサーリンク
概要
- 論文の詳細を見る
Effects of local anesthetics, tetrodotoxin (TTX), aconitine and verapamil on the rate of afferent discharges from the mechanoreceptors of isolated hearts of the bullfrog were studied. When procaine (1×10<SUP>-4</SUP>M), tetracaine (1×10<SUP>-6</SUP>M) and dibucaine (1×10<SUP>-5</SUP>M) decreased the contractile force and beating rate of the heart, high frequency discharges that were synchronized with the contraction of the heart appeared. When concentrations of these local anesthetics were increased, the afferent discharges were abolished. When TTX (1×10<SUP>-8</SUP>M-1×10<SUP>-7</SUP> M) caused a cardiac arrest, high frequency discharges, consisting of maintained discharges and the discharges synchronized with small contractions of the ventricle, appeared. Occasionally, in the presence of TTX (1×10<SUP>-7</SUP> M) the cardiac arrest occurred, and then very irregular contractions appeared. At that time, high frequency discharges synchronized with contractions appeared. On the other hand, aconitine (1×10<SUP>-7</SUP>M-1×10<SUP>-6</SUP> M) initially increased the rate of afferent discharges from mechanoreceptors in the atrium and ventricle and then abolished the discharges without significantly affecting beating rhythms and contractile force. When verapamil (1×10<SUP>-6</SUP>M-1×10<SUP>-5</SUP> M) was applied, the beating rate and contractile force were significantly decreased, but high frequency discharges synchronized with con tractions were observed. These results indicate that local anesthetics, TTX and verapamil at those concentrations which depressed the cardiac functions did not inhibit the heart mechanoreceptor excitability and the concentration of aconitine that markedly affected the cardiac functions stimulated the heart mechanoreceptor.
- 社団法人 日本薬理学会の論文
著者
-
KONTANI Hitoshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
-
Kontani Hitoshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Hokuriku University
-
KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
-
KONTANI Hitoshi
Department of Pharmacology, Hokuriku University, School of Pharmacy
-
KONTANI Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
-
KOSHIURA Ryozo
Department of Pharmacology, Hokuriku University, School of Pharmacy
-
Kontani Hitoshi
Departmenr of Pharmacology, Faculty of Pharmaceutical Science, Hokuriku University
関連論文
- Inhibitory Effects of Tetrandrine and Related Synthetic Compounds on Angiogenesis in Streptozotocin-Diabetic Rodents
- Combined effects of Stephania Radix and Astragali Radix in antihyperglycemic action of Boi-ogi-to (Fang-ji-huang-qi-tang) in streptozotocin-induced diabetic mice
- Effect of K^+ Channel Openers, KRN2391 and Ki1769, and Nitroglycerin on the Urinary Tract of Rats In Vivo
- Demonstration of Antiallodynic Effects of the Cyclooxygenase-2 Inhibitor Meloxicam on Established Diabetic Neuropathic Pain in Mice
- Comparison of the effects of percutaneous and intraduodenal administration of oxybutynin on bladder contraction and salivation in rabbits
- Sex difference in urethral response to electrical stimulation of efferent nerves in the pudendal sensory branch of rats
- Separate Recording of A-delta and C Fiber-Mediated Nociceptive Flexor Reflex Responses of Mouse Hindlimb Using Electromyography and the Characteristics of Wind-Up Appearing in the Responses
- A Quantitative Assay for Angiogenesis of Cultured Choroidal Tissues in Streptozotocin-Diabetic Wistar and Spontaneously Diabetic GK Rats
- Anti-hyperglycemic Effect of Fangchinoline Isolated from Stephania Tetrandra Radix in Streptozotocin-Diabetic Mice
- Effect of nicotine on the pelvic afferent nerve activity and bladder pressure in rats
- Method for Simultaneous Recording of the Prostatic Contractile and Urethral Pressure Responses in Anesthetized Rats and the Effects of Tamsulosin
- Effects of Adrenergic α_2-Receptor Agonists on Urinary Bladder Contraction in Conscious Rats
- Updated Japanese Urological Association Guidelines on prostate-specific antigen-based screening for prostate cancer in 2010
- Skeletal-related events in urological cancer patients with bone metastasis : A multicenter study in Japan
- COMPARATIVE STUDIES ON THE COMBINED CYTOTOXIC EFFECT OF FORSKOLIN WITH MITOMYCIN C AND RESPONSIVENESS TO FORSKOLIN IN RAT ASCITES HEPATOMA AH66 CELLS AND AH66F CELLS
- Urinary bladder Response to Hypogastric Nerve Stimulation After Bilateral Resection of the Pelvic Nerve or Spinal Cord Injury in Rats
- EFFECT OF MITOMYCIN C ON THE ACTIVATION OF ADENYLATE CYCLASE IN RAT ASCITES HEPATOMA AH130 CELLS
- EFFECTS OF LOCAL ANESTHETICS, TETRODOTOXIN, ACONITINE AND VERAPAMIL ON THE MECHANORECEPTORS OF ISOLATED FROG HEART
- RECORDING OF PULMONARY AFFERENT ACTIVITIES FROM RECEPTORS IN THE PERFUSED LUNG PREPARATION OF BULLFROG AND EFFECTS OF DRUGS ON THE AFFERENT ACTIVITIES
- EFFECTS OF METABOLIC INHIBITORS AND OUABAIN ON STATIC AFFERENT DISCHARGES FROM THE ISOLATED FROG MUSCLE SPINDLE
- EFFECTS OF LOCAL ANESTHETICS ON THE PULMONARY MECHANORECEPTORS OF THE PERFUSED FROG LUNG
- ENHANCEMENT OF MITOMYCIN C UPTAKE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA
- The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy
- Management for males whose female partners are diagnosed with genital chlamydial infection
- THE ACTION OF MITOMYCIN C ON THE INDUCTION OF CYCLIC AMP PHOSPHODIESTERASE AND THE DEVELOPMENT OF DESENSITIZATION OF ADENYLATE CYCLASE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA AH130 CELLS
- RELATIONSHIP BETWEEN ENHANCEMENT OF CYTOTOXIC EFFECT OF MITOMYCIN C AND INCREASE OF INTRACELLULAR CYCLIC ADENOSINE 3' : 5'-MONOphoSPHATE BY ISOPROTERENOL IN RAT ASCITES HEPATOMA CELLS
- EFFECT OF β-ADRENERGIC STIMULANTS ON CYTOTOXICITY OF MITOMYCIN C IN HeLa CELLS
- The future of urodynamics : Non-invasive ultrasound videourodynamics
- Spinal Muscarinic Recptor Subtypes Regulating Voiding In Rats
- Multiform Combination Effects of Smooth Muscle Relaxants with Antitumor Agents in Rat Ascites Hepatoma AH66 Cells
- Paclitaxel, ifosfamide, and nedaplatin as second-line treatment for patients with metastatic urothelial carcinoma : A phase II study of the SUOC group
- Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland
- T2^*-weighted Image/T2-weighted Image Fusion in Postimplant Dosimetry of Prostate Brachytherapy
- Japanese guideline for clinical research of antimicrobial agents on urogenital infections : the first edition
- Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection
- Role of lymph node dissection in management of bladder cancer
- Clinical efficacy of levofloxacin 500mg once daily for 7 days for patients with non-gonococcal urethritis
- Comparative Studies on Antitumor Activity of Klebsiella 03 Lipopolysaccharide and Its Polysaccharide Fraction in Mice
- Guidelines for Smoking Cessation (JCS 2010) : Digest Version
- Impact of Stent Platform of Paclitaxel-Eluting Stents : Assessment of Neointimal Distribution on Optical Coherence Tomography
- Lymph node metastasis mapping in extended lymphadenectomy to the level of the inferior mesenteric artery for bladder cancer
- Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
- Myelodysplastic syndrome treated effectively with testosterone enanthate
- Exploring immune therapy for renal cancer
- New technique with combination of felt, Hem-o-lok and Lapra-Ty for suturing the renal parenchyma in laparoscopic partial nephrectomy
- Botulinum toxin type A for the treatment of lower urinary tract disorders
- Increase of sensitivity and uptake of vinblastine by reserpine in rat ascites hepatoma.
- Structure-activity relationship in N3-alkyl-xanthine derivatives.
- Studies on responsiveness of hepatoma cells to catecholamines. III Difference between the receptor-adenylate cyclase regulating systems in AH130 cells and cultured normal rat liver cells.
- Evaluation of drugs for treatment of urinary bladder dysfunction in conscious rats with intact pelvic nerve and after resection of the left pelvic nerve.
- Effects of central nervous system-acting drugs on urinary bladder contraction in unanesthetized rats.
- Effects of Levcromakalim on Ureteral Peristaltic Function and Cystometrogram in Rats.
- Antitumor activity of methanol extract from roots of Agrimonia pilosa Ledeb.
- Enhancement of the cytotoxic effect of mitomycin C by .BETA.-adrenergic stimulants in rat ascites hepatoma AH130 cells.
- Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa ledeb., on transplantable rodent tumors.
- Studies on responsiveness of hepatoma cells to catecholamines. I. Lack of .BETA.-adrenergic responsiveness in rat ascites hepatoma AH13 cells.
- Studies on responsiveness of hepatoma cells to catecholamines. IV Lack of adrenergic activation of phosphorylase in rat ascites hepatoma cells.
- Studies on responsiveness of hepatoma cells to catecholamines. II. Comparison of .BETA.-adrenergic responsiveness of rat ascites hepatoma cells with cultured normal rat liver cells.
- In vivo effects of drugs that act on the autonomic nervous system on the rat urinary bladder contraction accompanying micturition.
- The effects of tetrodotoxin, papaverine and verapamil on the increase in the rate of spontaneous afferent discharges induced by local anesthetics from the pulmonary mechanoreceptors of the bullfrog.
- Effects of Adrenergic Agonists on an Experimental Urinary Incontinence Model in Anesthetized Rabbits.
- Involvement of .ALPHA.2-Adrenoceptors in the Sacral Micturition Reflex in Rats.
- Antitumor activity of Klebsiella 03 lipopolysaccharide in mice.
- The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats.
- A study of morphine-induced urinary retention in anesthetized rats capable of micturition.
- Dopamine receptor subtypes that induce hyperactive urinary bladder response in anesthetized rats.
- In vivo inhibitory effects of stimulation at the central end of the pelvic nerve severed from urinary bladder on urinary bladder contraction in rats.
- Combined cytotoxic effect of isoproterenol with alkylating agents in HeLa cells.
- The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog.
- Effects of apomorphine on urinary bladder motility in anesthetized rats.