Dopamine receptor subtypes that induce hyperactive urinary bladder response in anesthetized rats.
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概要
- 論文の詳細を見る
In anesthetized rats, SKF 38393 (10 mg/kg, i.v.) did not facilitate urinary bladder motility, but bromocriptine (BR, 5 mg/kg, i.v.) alone and the combination of BR (1 mg/kg, i.v.) and SKF 38393 (1 mg/kg, i.v.) induced a hyperactive bladder response (HBR). Both HBR induced by BR alone or BR and SKF 38393 combined was suppressed by SCH 23390. sulpiride or haloperidol. These results indicate that HBR is mediated by the activation of D-2 receptors, and the effects of D-2 agonists on bladder motility are potentiated by the simultaneous stimulation of D-1 receptors.
- 公益社団法人 日本薬理学会の論文
著者
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Inoue Tsutomu
Department Of Nephrology Saitama Medical School
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KONTANI Hitoshi
Department of Pharmacology, Hokuriku University, School of Pharmacy
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Kontani Hitoshi
Departmenr of Pharmacology, Faculty of Pharmaceutical Science, Hokuriku University
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SAKAI TAKESHI
Department of Chemical Engineering, Gunma University
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