Valsartan Cardie-Renal Protection in Patients Undergoing Coronary Angiography Complicated With Chronic Renal Insufficiency (VAL-CARP) Trial : Rationale and Design(CLINICAL INVESTIGATION)
スポンサーリンク
概要
- 論文の詳細を見る
Background Despite an increase in the frequency of coronary angiography (CAG) in Japan, the exact incidence of contrast-induced nephropathy (CIN) remains unknown in the Japanese population, especially in patients with chronic renal insufficiency. In addition, the nature of pharmacological interventions that would benefit the patients before or after procedures such as coronary bypass graft (CABG) and percutaneous coronary intervention (PCI) has not been fully investigated. Methods In the trial 500 patients with renal insufficiency (defined as a glomerular filtration rate (GFR) of between 89 and 30ml・min^<-1>・(1.73m^<-2>) following CAG will be randomly assigned to receive either valsartan, an angiotensin receptor blocker or angiotensin converting enzyme (ACE) inhibitor plus valsartan. The primary end-point is a change in the GFR of patients, which will be followed up for 3 years, including following CABG surgery or PCI. The incidence of cardiac events as well as the adverse effects of pharmacological intervention will be evaluated. In addition, the incidence of renal artery stenosis at the time of CAG will be reported also; however, the patients with renal artery stenosis will be excluded from the present study. Conclusion The present study will provide data on: 1) the exact incidence and course of renal function of CIN after CAG; and 2) the comparative therapeutic benefit of pharmacological intervention with valsartan alone or with valsartan and an ACE inhibitor in combination in patients with coexisting coronary artery diseases and chronic renal insufficiency, regardless of whether they receive CABG or PCI. In addition to these studies, an estimate of the incidence of renal artery stenosis in these patients will be demonstrated.
- 2006-04-20
著者
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KYO Shunei
Department of Cardiothoracic Surgery, The University of Tokyo
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Nishimura Shigeyuki
Departments of Cardiology, Saitama Medical School
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MATSUMOTO Kazuo
Department of Cardiology, Saitama Medical University International Medical Center
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Ikeda Naofumi
Department of Nephrology, Saitama Medical School
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Komiyama Nobuyuki
Department of Cardiology Saitama Medical School
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Inoue Tsutomu
Department of Nephrology, Saitama Medical School
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Suzuki Hiromichi
epartment of Nephrology, Saitama Medical School
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Komiyama Nobuyuki
Division Of Cardiology Saitama Medical University International Medical Center
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Nishiyama Shinichiro
Division Of Cardiology Saitama Medical University International Medical Center
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Kyo Shunei
Department Of Cardiac Surgery Saitama Medical School
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Nishimura Shigeyuki
Department Of Cardiology Saitatama International Medical Center Saitama Medical Univeristy
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Nishimura Shigeyuki
Department Of Cardiology Saitama Medical University International Medical Center
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Ikeda Naofumi
Department Of Nephrology Saitama Medical School
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Inoue Tsutomu
Department Of Nephrology Saitama Medical School
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Nishimura Shigeyuki
Yokohama Rosai Hospital
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Nishimura Shigeyuki
Saitama Heart Institute Saitama Medical School
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Matsumoto Kazuo
Department Of Cardiology Saitama Medical University International Medical Center
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Kaneko Mutsuo
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Matsumoto Kazuo
Department Of Cardiology Saitatama International Medical Center Saitama Medical Univeristy
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Kaneko Matsuo
Division Of Ecg Fukuda Denshi Co.ltd.
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Nishimura Shigeyuki
Depertment Of Cardiology Saitama Medical University International Medical Center
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Suzuki Hiromichi
Epartment Of Nephrology Saitama Medical School
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Nishiyama Shiniciro
Saitama International Medical Center
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Nishiyama Shinichiro
Division Of Cardiology Cardiovascular Center Toranomon Hospital
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Nishimura Shigeyuki
Division Of Cardiology Saitama Medical University International Medical Center
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Matsumoto Kazuo
Department Of Cardiology Saitama Medical School
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Nishiyama Shinichiro
Toranomon Hospital
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Nishimura Shigeyuki
Department Of 2^<nd> Internal Medicine Saitama Medical School
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Komiyama Nobuyuki
Department Of Cardiology Saitatama International Medical Center Saitama Medical Univeristy
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Matsumoto Kazuo
Department Of Cardiology Saitama Medical University International Medical Center Saitama Medical Uni
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Nishiyama Shinichiro
Department Of Cardiology Saitama Medical University International Medical Center
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Komiyama Nobuyuki
Department Of Cardiology Saitama International Medicin Center
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Nishiyama Shinichirou
Cardiovascular Center Toranomon Hospital
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Inoue Tsutomu
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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