Dynamic Patch Artificial Myocardium; Effects on the Residual Myocardial Function : SYMPOSIUM ON ARTIFICIAL CONTROL OF CIRCULATION : EXPERIMENTAL RESULTS AND CLINICAL APPLICATIONS

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概要

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• Dynamic patch artificial myocardium (D-PATCH) has been developed to replace the damaged left ventricular (LV) wall in severe cardiogenic shock patients with a massive myocardial infarction. This study was undertaken to demonstrate the effects of (1) single D-PATCH support on the global cardiac function (group 1, 12 dogs, whole heart model), (2) single D-PATCH support on the LV function and myocardial metabolism (group 2, 6 dogs, right heart bypass model), and (3) the concomitant support of D-PATCH and aortic counterpulsation (CP) on the regional myocardial function of the residual LV wall (group 3, 6 dogs, right heart bypass model with ultrasonic piezoelectric crystals). In group 1, mean aortic pressure and cardiac output were increased 20-36% (p<0.01) and 17-50% (p<0.01) respectively, and mean left atrial pressure was decreased 16% (p<0.01) by D-PATCH assist. In group 2, under constant preload volume, afterload pressure and heart rate, tension time index (TTI) was decreased 21-26% (p<0.01) and myocardial oxygen consumption was also decreased 24-29% (p<0.001) by D-PATCH assist. In group 3, although peak LVP was increased by single D-PATCH assist, when heart was assisted concomitantly by D-PATCH and CP peak LVP was significantly decreased (18%, p<0.01). Percent LV segmental shortening was not increased by CP assist, but increased 143% (p<0.02) by D-PATCH assist. In conclusion, D-PATCH can improve the global LV function and myocardial metabolism of the ischemic failing heart, also improve the regional myocardial function of the residual LV wall. Thus, D-PATCH is effective for the salvage of ischemic myocardium while maintaining the global cardiac function.

• 社団法人日本循環器学会の論文
• 1984-03-20

著者

• KYO Shunei

  Department of Cardiothoracic Surgery, The University of Tokyo

• TAKAMOTO Shinichi

  Department of Cardiovascular Surgery, Mitsui Memorial Hospital

• Takamoto Shinichi

  Department Of Cardiovascular Surgery Mitsui Memorial Hospital

• Takamoto Shinichi

  東京大学 心臓外科･呼吸器外科

• Takamoto Shinich

  Showa General Hospital

• Kyo Shunei

  Department Of Cardiovascular Surgery Saitama Medical University

• Kyo Shunei

  Department Of Cardiac Surgery Saitama Medical School

• Takamoto Shinichi

  Department Of Cardiac Surgery The University Of Tokyo

• OMOTO Ryozo

  Department of Surgery, Saitama Medical School

• Omoto Ryozo

  Saitama Medical School

• Omoto Ryozo

  Department Of Surgery Saitama Medical School

• YOKOTE YUJI

  Department of Pediatric Cardiology and Cardiovascular Surgery, Saitama Heart Institute, Saitama Medi

• Yokota Yuji

  Saitama Medical School

• Emoto Hideto

  Department Of Surgery Saitama Medical School

• Takamoto Shinichi

  Showa General Hospital

• Omoto Ryozo

  The Department Of Surgery Saitama Medical School

• YAMANAKA HIDEO

  Department of Surgery, Saitama Medical School

• BUCKLEY MORTIMER

  Department of Surgery, Massachusetts General Hospital, Harvard Medical School

• AUSTEN W.

  Department of Surgery, Massachusetts General Hospital, Harvard Medical School

• Sakaguchi Taichi

  Department Of Cardiovascular Surgery Mitsui Memorial Hospital

• Omoto Ryuzo

  The Department Of Surgery Saitama Medical School

• Takamoto Shinichi

  Department Of Cardiac Surgery

• Buckley Mortimer

  Department Of Surgery Massachusetts General Hospital Harvard Medical School

• Austen W.

  Department Of Surgery Massachusetts General Hospital Harvard Medical School

• Yamanaka Hideo

  Department Of Surgery Saitama Medical School

• Yamanaka Hideo

  Department of Applied Physics, University of Tsukuba

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