Anti-infectious Activity of Tryptophan Metabolites in the L-Tryptophan-L-Kynurenine Pathway(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
To study the anti-infectious effect of a vascular allograft, the antimicrobial activity of tryptophan metabolites mediated by indoleamine 2,3-dioxygenase was determined. The growth of methicillin-resistant Staphylococcus aureus (MRSA) over 10h in extracts from post-transplantation vascular allograft was significantly slower than that of extracts from non-transplantation vascular allograft regardless of the presence of tryptophan (p<0.05). When the antimicrobial activity of the tryptophan metabolites in the L-tryptophan-L-kynurenine pathway was examined, 3-hydroxy-DL-kynurenine and α-picolinic acid had strong antibacterial activity against MRSA, S. epidermidis, Escherichia coli, and multidrug-resistant Pseudomonas aeruginosa, although antimicrobial activities of anthranilic acid, 3-hydroxyanthranilic acid, and quinolinic acid against them were low. The results showed that, of the tested tryptophan metabolites, 3-hydroxy-DL-kynurenine and α-picolinic acid contributed to the anti-infectious effects of the allograft by inhibiting of the growth of microorganisms.
- 社団法人日本薬学会の論文
- 2009-01-01
著者
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MOTOMURA Noboru
Department of Cardiothoracic Surgery, The University of Tokyo
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TAKAMOTO Shinichi
Department of Cardiovascular Surgery, Mitsui Memorial Hospital
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Motomura Noboru
Department Of Cardiothoracic Surgery The University Of Tokyo
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Motomura Noboru
東京大学 心臓外科学
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Takamoto Shinichi
Department Of Cardiovascular Surgery Mitsui Memorial Hospital
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Takamoto Shinichi
東京大学 心臓外科･呼吸器外科
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NOGUCHI Norihisa
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Narui Koji
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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SASATSU Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Takamoto Shinichi
Department Of Cardiothoracic Surgery The University Of Tokyo
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Takamoto Shinichi
From The Department Of Cardiothoracic Surgery Faculty Of Medicine University Of Tokyo
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Takamoto Shinichi
Department Of Cardiac Surgery The University Of Tokyo
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SAITO Aya
Department of Cardiothoracic Surgery, Graduate School of Medicine, The University of Tokyo
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KAKIMI Kazuhiro
Department of Immunotherapeutics (Medinet), Graduate School of Medicine, The University of Tokyo
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KUBO Kinya
Discovery Research Laboratories, Research Division, Kirin Pharma Company, Limited
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Kubo Kinya
Discovery Research Laboratories Research Division Kirin Pharma Company Limited
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Kakimi Kazuhiro
Department Of Immunotherapeutics (medinet) Graduate School Of Medicine The University Of Tokyo
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Kakimi Kazuhiro
Department Of Bioregulation Mie University School Of Medicine
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Takamoto Shinichi
Department Of Cardiothoracic Surgery The University Of Tokyo Graduate School Of Medicine
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MOTOMURA Noboru
the Departments of Cardiothoracic Surgery University of Tokyo
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Noguchi Norihisa
Tokyo University Of Pharmacy And Life Science
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Nishimura Moyonobu
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Nishimura Motonobu
First Department Of Surgery And Department Of Physiological Chemistry Osaka University Medical Schoo
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Nishimura Motonobu
Department Of Cardiovascular Surgery Saitama Medical School
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Saito Aya
Department Of Cardiothoracic Surgery Graduate School Of Medicine The University Of Tokyo
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Sasatsu M
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Sasatsu Masanori
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Motomura Noboru
Department Of Cardiac Surgery University Of Tokyo
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Nishimura Motonobu
First Department Of Surqery Osaka University Medical School
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Sakaguchi Taichi
Department Of Cardiovascular Surgery Mitsui Memorial Hospital
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Takamoto Shinichi
Department Of Cardiac Surgery
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Takamoto Shinichi
Department Of Cardiovascular Surgery University Of Tokyo
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Nishimura Motonobu
Department Of Cardiothoracic Surgery The University Of Tokyo
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Motomura Noboru
Department Of Cardiac Surgery Faculty Of Medicine Graduate School Of Medicine University Of Tokyo
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Saito Aya
Department Of Animal Sciences Faculty Of Agriculture Iwate University
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Kubo Kinya
Discovery Research Laboratories Research Division Kirin Pharma Company
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Nishimura Moyonobu
Department of Cardiothoracic Surgery, The University of Tokyo Hospital
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Sasatsu Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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