Usefulness of Rapid Quantitative Measurement of Myoglobin and Troponin T in Early Diagnosis of Acute Myocardial Infarction

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Background New equipment, the Cardiac Reader・, which can measure blood concentrations of troponin T (T) and myoglobin (M) in only 15min at the bedside was evaluated for early diagnosis of acute myocardial infarction (AMI). Methods and Results A total of 34 consecutive patients with AMI who came to hospital within 24h after onset were studied. Blood samples were collected from the patients at admission and 6, 12, 24, 48h after onset to qualitatively and quantitatively measure T, M and creatine kinase-MB fraction. There were 20 patients with positive results by qualitative troponin T test and 29 with positive results by quantitative test. Of the patients who visited hospital within 3h of onset, 17% were positive by the qualitative test and 67% cases had positive results in the quantitative test. The patients were divided into 2 groups according to the flow grade in the infarct-related coronary artery. In the TIMI 0-1 group (n=28), serum myoglobin concentrations were higher than in the TIMI 3-4 group (n=6) at admission and at their peak. Conclusion The rapid quantitative test of T and M is useful for early diagnosis of AMI and as an indicator of its severity, which can be evaluated from the myoglobin concentration in the hyper-acute phase.
社団法人日本循環器学会の論文
2004-06-20