Role of Relative Myocardial Perfusion Reserve for Evaluating Stenosis Severity in Patients With Single-Vessel Coronary Artery Disease Using [^<13>N] Ammonia and Positron Emission Tomography

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• A statistically significant correlation was observed between the severity of anatomic stenosis and coronary flow reserve in experimental animals. A similar correlation in human coronary artery disease(CAD) was shown using positron emission tomography(PET) and pharmacologic vasodilator stress. The present study tested whether the concept of relative myocardial perfusion reserve(MPR) might be superior to absolute MPR in correlating coronary stenosis determined by quantitative coronary arteriography in patients with single vessel CAD using [^<13>N]ammonia and PET. The study group comprised 21 patients (62±10 years old; 15 men, 6 women) with normal left ventricular function who underwent angioplasty for isolated left anterior descending coronary artery stenosis. Absolute MPR, the ratio of dipyridamole-induced hyperemic blood flow to baseline blood flow by [^<13>N]ammonia PET, and relative MPR, the ratio of MPR in regions supplied by stenosed coronary arteries to MPR in remote regions, were measured before and 3 months after angioplasty. The percent diameter stenosis was also quantified on coronary arteriograms just before the angioplasty and again at 3 months after. The study found that absolute MPR (r=0.755; p<0.0001) and relative MPR (r=0.814; p<0.0001) were inversely and nonlinearly correlated with the percent stenosis on angiography. The fitting curve of the correlation between relative MPR and coronary stenosis on angiography was identical to that observed in animal models. Therefore, relative MPR measured by [^<13>N]ammonia PET more accurately and specifically describes stenosis severity in patients with CAD compared with absolute MPR, probably because of its independence from hemodynamic variations and the effects of coronary risk factors.

• 社団法人日本循環器学会の論文
• 2000-12-20

著者

• Masuda Yoshiaki

  Department Of Cardiology Chiba Rosai Hospital

• Watanabe Shigeru

  The Japanese Society Of Ct Screening

• Watanabe Shigeru

  Third Department Of Internal Medicine Chiba University School Of Medicine

• Yoshida K

  Department Of Cardiology Kawasaki Medical School

• Watanabe Satoshi

  千葉大学 第3内科

• Odaka Kenichi

  Molecular Imaging Center, National Institute of Radiological Sciences

• Odaka Kenichi

  Molecular Imaging Center National Institute Of Radiological Sciences

• Yoshida Katsuya

  Department Of Internal Medicine Iii Osaka Medical College

• Odaka Kenichi

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Yoshida Katsuya

  Third Department Of Internal Medicine Chiba University School Of Medicine

• WATANABE Satoshi

  Third Department of Internal Medicine, Chiba University School of Medicine

• FUJIWARA Masaki

  Third Department of Internal Medicine, Chiba University School of Medicine

• MASUDA Yoshiaki

  Third Department of Internal Medicine, Chiba University School of Medicine

• Odaka Kenichi

  National Institute of Radiological Sciences

• Masuda Yoshiaki

  The Japanese Society Of Ct Screening

• NAKAGAWA Keiichi

  Third Division ,Department of Internal Medicine,Chiba University

• Tamura Takashi

  Tobu Chiiki Hospital

• Odaka Kenichi

  Third Department of Internal Medicine, Chiba University School of Medicine

• Satoh Mikio

  Third Department of Internal Medicine, Chiba University School of Medicine

• Miyamoto Keicho

  Tobu Chiiki Hospital

• Satoh Mikio

  Third Department Of Internal Medicine Chiba University School Of Medicine

• Yoshida Katsuya

  National Institute Of Radiological Sciences Nagoya University Graduate School

• Fujiwara Masaki

  Third Department Of Internal Medicine Chiba University School Of Medicine

• Masuda Yoshiaki

  Chiba Univ.

• Masuda Yoshiaki

  Third Department Of Internal Medicine Schoolof Medicine Chiba University

• Nakagawa Keiichi

  Third Department Of Internal Medicine Chiba University School Of Medicine

• Nakagawa Keiichi

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Watanabe Shigeru

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Masuda Yoshiaki

  3rd. Department Of Internal Medicine School Of Medicine Chiba University

• Masuda Yoshiaki

  Third Department Of Internal Medicine Chiba University

• Masuda Yoshiaki

  The Third Dept. Of Internal Medicine Chiba University School Of Medicine

• Watanabe Sigeru

  Third Department Of Internal Medicine Chiba University School Of Medicine

• Masuda Yoshiaki

  2nd Div. Dept. Of Intern. Med. School Of Medicine Chiba University

• Matsuoka Yushi

  The Third Department Of Internal Medicine Chiba University School Of Medicine

• Masuda Yoshiaki

  The Third Department Of Internal Medicine Chiba University School Of Medicine Chiba

• Masuda Yoshiaki

  The Third Departments Of Internal Medicine

• Watanabe Shigeru

  The Third Dept. Of Intern. Med. Chiba Univ. School Of Med.

• Watanabe Shigeru

  Graduate School Of Medicine Chiba University

• Watanabe Shigeru

  The Third Departments Of Internal Medicine

• Watanabe Shigeru

  The Third Clinical Department Of Internal Medicine Chiba University School Of Medicine

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