Anti-hyperglycemic Effect of Fangchinoline Isolated from Stephania Tetrandra Radix in Streptozotocin-Diabetic Mice

スポンサーリンク

概要

• 論文の詳細を見る

• Kampo medicine, Stephania tetrandra Radix (Stephania) in Boi-ogi-to increases the blood insulin level and falls the blood glucose level in streptozotocin (STZ) -diabetic ddY mice. These actions of Stephania are potentiated by Astragalus membranaceus Bunge Radix (Astragali) in Boi-ogi-to (Liu et al. , J. Traditional Med. , 17, 253260, 2000). In the present study, actions of bis-benzylisoquinoline alkaloids isolated from Stephania were investigated in the hyperglycemia of STZ-diabetic mice. A main bis-benzylisoquinoline alkaloid, fangchinoline (0. 33 mg/kg) significantly fell the blood glucose level of the diabetic mice in a dose-dependent manner. The effect of fangchinoline was 3. 9-fold greater than that of water extract of Stephania. However, another main compound, tetrandrine (1-100 mg/kg) did not have any effect. The water extract of Astragali did not affect singly but potentiated the anti-hyperglycemic action of fangchinoline (0. 3 mg/kg). Out of used compounds (1 mg/kg) isolated from Stephania, fangchinoline, fangchinoline 2'-N-α-oxide and 2'-N-norfangchinoline, which are substituted with 7-hydroxy side chain for 7-O-methyl side chain, decreased to near 50% of high blood glucose level. In addition, tetrandrine 2'N-β-oxide, tetrandrine 2'-N-α-oxide, tetrandrine 2-N-β-oxide, fangchinoline 2'-N-α-oxide, which are added to 2- or 2'-N-oxide side chain, also decreased to near 50% of the high blood glucose level. In conclusion, fangchinoline but not tetrandrine from Stephania shows the anti-hyperglycemic action in the STZ-diabetic mice. The demethylation of 7-O-position and/or addition of 2- or 2'-N-oxide side chain in bis-benzylisoquinoline compounds in Stephania have a role for the induction of the anti-hyperglycemic actions.

• 公益社団法人日本薬学会の論文
• 2003-03-01

著者

• KOBAYASHI Shinjiro

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• KONTANI Hitoshi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• Liu Yuan

  Department of Oral Histology and Pathology, Qin Du Stomatological Cofiege, the Fourth Military Medic

• Kontani H

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Kontani H

  Hokuriku Univ. Kanazawa Jpn

• Liu Y

  Department Of Traditional Chinese Medicine Faculty Of Pharmaceutical Sciences Hokuriku University

• TSUTSUMI Taiki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences Hokuriku University

• Tsutsumi Taiki

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Kobayashi Shinjiro

  Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University

• Kontani Hitoshi

  Department Of Pharmacology Faculty Of Pharmaceutical Science Hokuriku University

• Tsutsumi T

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Liu Yuan

  Department Of Environmental And Natural Resource Science Faculty Of Agriculture Tokyo University Of

• Liu Yuan

  Department Of Catalysis Sciences And Technology School Of Chemical Engineering Tianjin University

• KONTANI Hitoshi

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

• Kontani Hitoshi

  Departmenr of Pharmacology, Faculty of Pharmaceutical Science, Hokuriku University

• Kobayashi Shinjiro

  Department of Applied Chemistry, Faculty of Engineering, Kyushu University

関連論文

• Overproduction of N^ε-(Carboxymethyl)lysine-Induced Neovascularization in Cultured Choroidal Explant of Streptozotocin-Diabetic Rat(Pharmacology)
• N^ε- (Carboxymethyl) lysine Proliferated CD34^+ Cells from Rat Choroidal Explant in Culture(Pharmacology)
• Inhibitory Effects of Tetrandrine and Related Synthetic Compounds on Angiogenesis in Streptozotocin-Diabetic Rodents
• Inhibitory Effects of Tetrandrine on Angioegnesis in Adjuvant-Induced Chronic Inflammation and Tube Foramation of Vascular Endothelial Cells
• The Diabetic State Increases the Activity but Not the Number of Peritoneal Macrophages in the GK Rat Promoting the Tube Formation of Cultured Endothelial Cells in Rat Aorta
• Suppression by High Glucose Concentration of Insulin Receptor Up-Regulation in Diaphragm and Flexor Digitorum Brevis Muscles from Diabetic KK-CA^y and Streptozotocin-Diabetic Mice
• Diabetic State-Induced Modification of Insulin-Stimulated, Glucose Uptake into and Kinase Activity in, the Diaphragm Muscle of Genetically Diabetic KK-CA^y Mice
• Perspective of Phospholipase A_2 involved in Acetylcholine Receptor Cluster Formation of Mouse Myotubes co-cultured with Spinal Cord Explant
• COMPARISON OF MECHANISMS OF ACTIONS BETWEEN CHOLECYSTOKININ AND PAPAVERINE FOR RELAXING A SPHINCTER OF ODDI IN HOG
• IMMUNOCHEMICAL EVIDENCE FOR INTERACTION BETWEEN CHOLECYSTOKININ C-TERMINAL PEPTIDES AND THE PROTEIN INHIBITOR OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE DEPENDENT PROTEIN KINASE IN HOG TERMINAL BILE DUCTS
• Bone-inducing ability of lyophilized periosteum (dura mater) with rhBMP-2 and TGF-β
• Inhibitory Effects of Traditional Chinese Medicine Shimotsu-to and Its Included Crude Fractions on Adjuvant-Induced Chronic Inflammation of Mice
• Combined effects of Stephania Radix and Astragali Radix in antihyperglycemic action of Boi-ogi-to (Fang-ji-huang-qi-tang) in streptozotocin-induced diabetic mice
• Effect of K^+ Channel Openers, KRN2391 and Ki1769, and Nitroglycerin on the Urinary Tract of Rats In Vivo
• Demonstration of Antiallodynic Effects of the Cyclooxygenase-2 Inhibitor Meloxicam on Established Diabetic Neuropathic Pain in Mice
• Comparison of the effects of percutaneous and intraduodenal administration of oxybutynin on bladder contraction and salivation in rabbits
• Sex difference in urethral response to electrical stimulation of efferent nerves in the pudendal sensory branch of rats
• Characterization of Glycoside Hydrolase Family 6 Enzymes from Coprinopsis cinerea
• Separate Recording of A-delta and C Fiber-Mediated Nociceptive Flexor Reflex Responses of Mouse Hindlimb Using Electromyography and the Characteristics of Wind-Up Appearing in the Responses
• Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells
• Inhibitory Effect of Nifedipine on Tumor Necrosis Factor α-Induced Neovascularization in Cultured Choroidal Explants of Streptozotocin-Diabetic Rat(Pharmacology)
• A Quantitative Assay for Angiogenesis of Cultured Choroidal Tissues in Streptozotocin-Diabetic Wistar and Spontaneously Diabetic GK Rats
• Anti-hyperglycemic Effect of Fangchinoline Isolated from Stephania Tetrandra Radix in Streptozotocin-Diabetic Mice
• Effect of nicotine on the pelvic afferent nerve activity and bladder pressure in rats
• Combined Effects of Fangchinoline from Stephania Tetrandra Radix and Formononetin and Calycosin from Astragalus membranaceus Radix on Hyperglycemia and Hypoinsulinemia in Streptozotocin-Diabetic Mice(Pharmacology)
• Overproduction of N^ε-(Carboxymethyl)lysine-Induced Neovascularization in Cultured Choroidal Explant of Aged Rat(Pharmacology)
• Method for Simultaneous Recording of the Prostatic Contractile and Urethral Pressure Responses in Anesthetized Rats and the Effects of Tamsulosin
• Effects of Adrenergic α_2-Receptor Agonists on Urinary Bladder Contraction in Conscious Rats
• Effect of Flunarizine on Arterial Thrombosis after Endarterectomy in Rats
• Protective Effects of Toki-Shakuyaku-San Tsumra Japan-23(TJ-23)on β-Amyloid Protein(β40)-induced Apoptosis in Pheochromocytoma-12(PC12)Cells
• Eco-friendly Synthesis of m-Tolunitrile by Heterogeneously Catalysed Liquid Phase Ammoxidation
• Updated Japanese Urological Association Guidelines on prostate-specific antigen-based screening for prostate cancer in 2010
• Skeletal-related events in urological cancer patients with bone metastasis : A multicenter study in Japan
• Urinary bladder Response to Hypogastric Nerve Stimulation After Bilateral Resection of the Pelvic Nerve or Spinal Cord Injury in Rats
• EFFECTS OF LOCAL ANESTHETICS, TETRODOTOXIN, ACONITINE AND VERAPAMIL ON THE MECHANORECEPTORS OF ISOLATED FROG HEART
• RECORDING OF PULMONARY AFFERENT ACTIVITIES FROM RECEPTORS IN THE PERFUSED LUNG PREPARATION OF BULLFROG AND EFFECTS OF DRUGS ON THE AFFERENT ACTIVITIES
• EFFECTS OF METABOLIC INHIBITORS AND OUABAIN ON STATIC AFFERENT DISCHARGES FROM THE ISOLATED FROG MUSCLE SPINDLE
• EFFECTS OF LOCAL ANESTHETICS ON THE PULMONARY MECHANORECEPTORS OF THE PERFUSED FROG LUNG
• Gas Phase Substituent Effect on Basicity of Phenylacetylene. Intrinsic Resonance Demand of Phenylvinyl Cation
• Characterization of Glycoside Hydrolase Family 6 Enzymes from Coprinopsis cinerea
• The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy
• Management for males whose female partners are diagnosed with genital chlamydial infection
• The future of urodynamics : Non-invasive ultrasound videourodynamics
• Effects of Cellulose Crystallinity, Hemicellulose, and Lignin on the Enzymatic Hydrolysis of Miscanthus sinensis to Monosaccharides
• Relationships of anatomical characteristics versus shrinkage and collapse properties in plantation-grown eucalypt wood from China
• Spinal Muscarinic Recptor Subtypes Regulating Voiding In Rats
• Paclitaxel, ifosfamide, and nedaplatin as second-line treatment for patients with metastatic urothelial carcinoma : A phase II study of the SUOC group
• Highly Active and Selective Nickel-Cerium(IV) Oxide Catalyst for Water-Gas Shift Reaction
• Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland
• T2^*-weighted Image/T2-weighted Image Fusion in Postimplant Dosimetry of Prostate Brachytherapy
• Japanese guideline for clinical research of antimicrobial agents on urogenital infections : the first edition
• Splenomegaly in FOLFOX-naive stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy
• Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection
• Role of lymph node dissection in management of bladder cancer
• Clinical efficacy of levofloxacin 500mg once daily for 7 days for patients with non-gonococcal urethritis
• Guidelines for Smoking Cessation (JCS 2010) : Digest Version
• Upregulation of IRS-1 Expression in Goto-Kakizaki Rats Following Roux-en-Y Gastric Bypass Surgery : Resolution of Type 2 Diabetes?
• Impact of Stent Platform of Paclitaxel-Eluting Stents : Assessment of Neointimal Distribution on Optical Coherence Tomography
• Lymph node metastasis mapping in extended lymphadenectomy to the level of the inferior mesenteric artery for bladder cancer
• Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
• Myelodysplastic syndrome treated effectively with testosterone enanthate
• Exploring immune therapy for renal cancer
• New technique with combination of felt, Hem-o-lok and Lapra-Ty for suturing the renal parenchyma in laparoscopic partial nephrectomy
• Botulinum toxin type A for the treatment of lower urinary tract disorders
• Tetrandrine Prevents Bone Loss in Sciatic-Neurectomized Mice and Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclast Differentiation
• Chemical Structure-Activity of Cnidium Rhizome-Derived Phthalides for the Competence Inhibition of Proliferation in Primary Cultures of Mouse Aorta Smooth Muscle Cells.
• Antiproliferative Effects of the Traditional Chinese Medicine Shimotsu-To, Its Component Cnidium Rhizome and Derived Compounds on Primary Cultures of Mouse Aorta Smooth Muscle Cells.
• Changes in Messenger Ribonucleic Acid Species in Gerbil Brain Perturbation
• Studies of carbenium ion on unsaturated carbon. II. Exclusive formation of benzofurans via vinyl cations in the solvolytic reactions of 1-aryl-2,2-bis(o-methoxyphenyl)vinyl halides.
• Evaluation of drugs for treatment of urinary bladder dysfunction in conscious rats with intact pelvic nerve and after resection of the left pelvic nerve.
• Effects of central nervous system-acting drugs on urinary bladder contraction in unanesthetized rats.
• Effects of Levcromakalim on Ureteral Peristaltic Function and Cystometrogram in Rats.
• Abnormal Fatty Acid Composition of Lymphocytes of Biotin-Deficient Rats.
• Succinylcholine-Induced Acceleration and Suppression of Electrically Evoked Acetylcholine Release from Mouse Phrenic Nerve-Hemidiaphragm Muscle Preparation.
• Intracellular Ca2+ and Mg2+ Regulation for Insulin-Stimulated Glucose Uptake into Mouse Diaphragm Muscles.
• In vivo effects of drugs that act on the autonomic nervous system on the rat urinary bladder contraction accompanying micturition.
• Inhibitory Effects of Magnoshinin and Magnosalin, Compounds from "Shin-i" (Flos Magnoliae), on the Competence and Progression Phases in Proliferation of Subcultured Rat Aortic Endothelial Cells.
• The effects of tetrodotoxin, papaverine and verapamil on the increase in the rate of spontaneous afferent discharges induced by local anesthetics from the pulmonary mechanoreceptors of the bullfrog.
• Effects of Adrenergic Agonists on an Experimental Urinary Incontinence Model in Anesthetized Rabbits.
• Involvement of .ALPHA.2-Adrenoceptors in the Sacral Micturition Reflex in Rats.
• The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats.
• A study of morphine-induced urinary retention in anesthetized rats capable of micturition.
• Dopamine receptor subtypes that induce hyperactive urinary bladder response in anesthetized rats.
• In vivo inhibitory effects of stimulation at the central end of the pelvic nerve severed from urinary bladder on urinary bladder contraction in rats.
• The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog.
• Effects of apomorphine on urinary bladder motility in anesthetized rats.
• Heparin Inhibits the Progression Phase of Subcultured Endothelial Cell Proliferation in Rat Aorta.

もっと見る 閉じる

スポンサーリンク