Chemical Structure-Activity of Cnidium Rhizome-Derived Phthalides for the Competence Inhibition of Proliferation in Primary Cultures of Mouse Aorta Smooth Muscle Cells.
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概要
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Inhibitory effects of cnidium rhizome-derived phthalides on competence and progression phases of fetal bovine serum (10%)-induced proliferation were compared in primary cultures of mouse aorta smooth muscle cells (SMC). Their potencies for the competence inhibition were in the order of senkyunolide L ((<I>Z</I>)-6-hydroxy-7-chloro-6, 7-dihydroligustilide) > senkyunolide H (((<I>Z</I>)-6, 7-dihydroxy-6, 7-dihydroligustilide) > senkyunolide J ((3<I>S</I>)-(<I>E</I>)-6, 7-dihydroxy-3, 6, 7, 8-tetrahydroligustilide) > senkyunolide I ((<I>E</I>)-6, 7-dihydroxy-6, 7-dihydroligustilide) > ligustilide = senkyunolide A ((3<I>S</I>)-3, 8-dihydroligustilide) > butylidenephthalide. The order of their potencies for the progression inhibition was parallel with that for the competence inhibition. Senkyunolide L is considered to have been formed during the extraction of cnidium. These results demonstrate that the ((<I>Z</I>)-6, 7-dihydroxy isomer of the dihydroligustilide derivatives is essential for the anti-competent effect on proliferation of the SMC in primary culture. Senkyunolide H in cnidium rhizome may be a prototype for a new anti-atherosclerotic drug.
著者
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Naitoh Takeshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Mimura Yasuhiko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kobayashi Shinjiro
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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