THE PATTERN OF ACTION OF BLENDED CHINESE TRADITIONAL MEDICINES TO GLUCOSE TOLERANCE CURVES IN GENETICALLY DIABETIC KK-CA^y MICE
スポンサーリンク
概要
- 論文の詳細を見る
The effects of blended Chinese traditional medicines applied for diabetes mellitus were studied on the pattern of action to the glucose tolerance curves in genetically diabetic KK-CA^y mice. The glucose tolerance curves of KK-CA^y mice (humping curve) were analyzed pharmacokinetically by the mathematical model (Compartment-H model). The curves could be classified into several types of pattern through the analysis for the humping effect. Daisaikoto-Ka-Jio and Byakko-Ka-Ninjinto reduced the humping effect, whereas Hachimigan had a tendency to enhance it. On the combined effect of crude drugs prescribed in the blended medicines, the effect of Daisaikoto was lessened by subtracting Rehmanniae Rhizoma from Daisaikoto-Ka-Jio and Byakkoto (subtracted Ginseng Radix from Byakko-Ka-Ninjinto) had no inhibitory effect on the humping. Rehmanniae Rhizoma or Ginseng Radix alone had the similar effect on decreasing the humping. The hypoglycemic component of Ginseng Radix (DPG3-2) decreased the humping effect in a dose-dependent manner. In conclusion, the effects of crude drugs and the active component of the crude drug supported those of the blended medicines on the humping effect by utilizing the pharmacokinetical analysis.
- 公益社団法人日本薬学会の論文
著者
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SUZUKI Jun
Department of Health Care Chemistry, College of Environmental Health, Azabu University
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Suzuki Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Kimura Masayasu
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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