Micro two-dimensional electrophoretic analysis of changes in plasma proteins of next-generation rat of the pregnant rats administered to coplanar PCBs
スポンサーリンク
概要
- 論文の詳細を見る
Polychlorinated biphenyl (PCB) 126 or PCB 169 was administered to pregnant rats and kinetic changes in plasma protein spots of their next generation (F2 rats) ages 1, 3, 6, and 15 weeks were observed by micro two-dimensional polyacrylamide gel electrophoresis (M2D-PAGE). In the control group in which age-related changes were observable, changes in the form of the albumin (Alb) spot were recognized at ages 1-3 weeks. Only the Alb spot on the acid side, i.e., non-mercaptoalbumin, was recognized at age 1 week. At age 3 weeks, the Alb spot on the alkaline side, i.e., mercaptoalbumin, also became observable. On the other hand, qualitative changes in the form of Alb, i.e., manifestations of mercaptoalbumin, were recognized at age 1 week by administration of PCB 126. This result suggested that the influence of PCB 126 on the living body is greater than that of PCB 169. In spite of the treatment for toxicity by equivalence of dose control on the basis of toxicity equivalency factor (TEF) 0.1 for PCB 126 (PeCB) and 0.01 for PCB 169 (HxCB), the influence of PCB 126 on the living body was greater than that of PCB 169. The C3 spot was increased at age 3 weeks in the PCB 126 and the PCB 169. The spot showed a tendency toward increase at age 6 weeks in the PCB 126. The TEF compared PCB169 with PCB126, and distinctly increase of the C3 spot was observed for 15 weeks though the TEF was low. From these, as for the PCB 169, it was suggested appearing remarkably in aging influence of the immunity toxicity. The observations of the changes in these spots led to the conclusion that the changes in these spots resulted from transfer of the drugs accumulating in the maternal body to the F2 rats of the maternal rats administered PCB 126 and those administered PCB 169 via the breast milk and that these changes are involved with inflammatory proteins, including the target genes influenced by the toxicity of coplanar PCBs.
- 2006-12-01
著者
-
SAKAGUCHI Kazuko
Department of Health Care Chemistry, College of Environmental Health, Azabu University
-
SUZUKI Jun
Department of Health Care Chemistry, College of Environmental Health, Azabu University
-
TANAKA Masaki
Department of Health Care Chemistry, College of Environmental Health, Azabu University
-
SHIRAI Mituyuki
Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University
-
AKAHORI Fumiaki
Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University
-
坂口 和子
Department Of Health Care Chemistry College Of Environmental Health Azabu University
-
赤堀 文昭
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University
-
Suzuki Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
田中 雅樹
Department Of Health Care Chemistry College Of Environmental Health Azabu University
-
Akahori Fumiaki
Department Of Pharmacology School Of Veterinary Medicine Azabu University
-
Akahori Fumiaki
Department Of Environmental Health Jichi Medical School : National Institute Of Industrial Health :
-
Shirai Mituyuki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University
-
Sakaguchi Kazuko
Department Of Food Biochemistry School Of Life And Environmental Science Azabu University
-
Tanaka Masaki
Department Of Health Care Chemistry College Of Environmental Health Azabu University
-
Suzuki Jun
Department Of Health Care Chemistry College Of Environmental Health Azabu University
-
Tanaka Masaki
Department Of Anatomy & Neurobiology Kyoto Prefectural University Of Medicine
-
Sakaguchi Kazuko
Laboratory Of Pathologic Biochemistry School Of Environmental Health Sciences Azabu University
-
Suzuki Jun
Department Of Cardiology Saiseikai Saijo Hospital
関連論文
- Long-Term Epoprostenol Therapy in Pulmonary Artery Hypertension : Sequence of Changes in Hemodynamic Effects(Pulmonary Circulation)
- OE-160 Evaluation of Drug Eluting Stent Fracture in RCA Lesion by 64-slice Multislice Computed Tomography(OE27,CT/MRI (Coronary/Vascular) 1 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Micro two-dimensional electrophoretic analysis of changes in plasma proteins of next-generation rat of the pregnant rats administered to coplanar PCBs
- Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy
- FRS-024 Impact of Synergistic Polymorphisms in Adrenergic Receptor Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Me
- OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An
- OE-037 Combined Analysis of Polymorphisms in Inflammation-Related Genes and Their Effects on Atrial fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific
- PJ-606 Pulmonary Veno-occlusive Disease : Acute Vasodilator Response and Prognosis(PJ102,Pulmonary Circulation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-445 Renin-Angiotensin System Plays an Important Role in Diabetes Mellitus-Induced Diastolic Dysfunction in Hypertensive Rats(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- FRS-024 Impact of Synergistic Polymorphisms in Adrenergic Receptor Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Me
- OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An
- OE-037 Combined Analysis of Polymorphisms in Inflammation-Related Genes and Their Effects on Atrial fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific
- Intracoronary Administration of a Thromboxane A_2 Synthase Inhibitor Relieves Acetyicholine-Induced Coronary Spasm
- Circadian variation of vascular endotherial function - correalation with neurohormonal agents
- Magnesium Deficiency in Patients With Recent Myocardial Infarction and Provoked Coronary Artery Spasm
- Beneficial Effect of Troglitazone, an Insulin-Sensitizing Antidiabetic Agent, on Coronary Circulation in Patients With Non-Insulin-Dependent Diabetes Mellitus
- Subacute and Chronic Effects of DDD Pacing on Left Ventricular Diastolic Function in Ptients With Non-Obstructive Hypertrophic Cardiomyopathy
- Clinical Characteristics of Female Patients With Coronary Spastic Angina : Comparison With Male Patients
- Analysis by High-performance Anion-exchange Chromatography of Component Sugars as Their Fluorescent Pyridylamino Derivatives(Analytical Chemistry)
- Improved Method for Fluorescence Labeling of Sugar Chains with Sialic Acid Residues(Analytical Chemistry)
- Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats
- Portopulmonary Hypertension : Hemodynamics, Pulmonary Angiography, and Configuration of the Heart
- PJ-083 Differentiation of Hypertrophic Cardiomyopathy from Hypertensive Heart Disease Using Two-Dimensional Strain Analysis(PJ014,Cardiomyopathy/Hypertrophy (Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circul
- PE-548 Clinical Implication of Global Strain Rate during Isovolumic Relaxation Time in Patients with Non-ischemic Dilated Cardiomyopathy(PE092,Echo/Doppler (Myocardium) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circul
- PE-114 A Novel Method for Measurement of Carotid Arterial Elastic Properties Using Two Dimensional Speckle Tracking Analysis(PE019,Echo/Doppler (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- OE-130 A Link between Catenoid Shape Configuration of Hypertrophied Septum and Regional Myocardial Function in Patients with Hypertrophic Cardiomyopathy(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of T
- OE-127 Right Ventricular Septal Pacing Preserves Left Ventricular Synchrony and Torsional Behavior in Comparison with Conventional Apical Pacing(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japan
- PJ-704 Possible Link Between Left Ventricular Systolic and Diastolic Dyssynchrony and Diastolic Function in Patients With Essential Hypertension(Hypertension, clinical(09)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- INVOLVEMENT OF GLUCOCORTICOID IN INSULIN-INDUCED ANGIOGENESIS OF ADJUVANT POUCH GRANULOMA IN DIABETIC MICE
- QUANTITATIVE METHOD FOR MEASURING ADJUVANT-INDUCED GRANULOMA ANGIOGENESIS IN INSULIN-TREATED DIABETIC MICE
- MOUSE GRANULOMA POUCH INDUCED BY FREUND'S COMPLETE ADJUVANT WITH CROTON OIL
- OE-117 Eplerenone, a Selective Aldosterone Receptor Antagonist, Inhibits Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- Role of interferon regulatory factor-1 (IRF-1) in the regulation of apoptosis in vascular remodeling; study using IRF-1 null mice
- Efficacy of Acute Inhalation of Nitric Oxide in Patients With Primary Pulmonary Hypertension Using Chronic Use of Continuous Epoprostenol Infusion
- Possible Effectiveness of Combination Therapy in Patients with Severe Pulmonary Hypertention
- PE-337 Inhibition of Rho-kinase Ameliorates Diastolic Heart Failure in Hypertensive Rats(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-135 Diabetes Mellitus Accelerates Left Ventricular Diastolic Dysfunction through Activation of Renin-angiotensin System in Hypertensive Rats(Cardiac function, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Ja
- PE-436 Rho-kinase Pathway Plays an Important Role in the Pathogenesis of Diastolic Heart Failure in Dahl Salt-Sensitive Hypertensive Rats(Heart failure, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-205 Impact of Diabetes Mellitus on Left Ventricular Diastolic Dysfunction in Dahl Salt-Sensitive Hypertensive Rats(Cardiac function, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Outcome of Long-term Epoprostenol Therapy in Patients with Pulmonary Arterial Hypertension (Pulmonary Circulation 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-169 Stent Underexpansion is Not Main Reason of In-Stent Restenosis after Silorimus-Eluting Stents Implantation with RCA Lesion(Coronary revascularization, PCI(09)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulati
- 5 Current Status and Future Direction of Multi Detector-row Computed Tomography for the Integrated Management of Coronary Artery Disease(Symposium 14 (SY-14) (I) New Horizon of CT, MR and PET in Diagnostic Cardiac Imaging,Special Program,The 72nd Annual S
- FRS-067 Microtubule Polymerization Plays an Important Role in the Pathogenesis of Cardiomyocyte Apoptosis(Heart Failure, Cardiac Remodeling and Cardiomyopathy 1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Micro two-dimensional electrophoretic analysis of antiprotease in plasma from rats and rabbits poisoned by paraquat
- Metal(CoSi_2)/Insulator(CaF_2) Resonant Tunneling Diode
- Epoprostenol Infusion Therapy Changes Angiographic Findings of Pulmonary Arteries in Patients With Idiopathic Pulmonary Arterial Hypertension
- OE-072 Pathogenetic Link between Microtubule Polymerization and Myocyte Apoptisis : Implication for Heart Failure(Cell death, apoptosis/necrosis (M) OE12,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
- Secretion of Bax-Like Protein into Systemic Circulation from the Posterior Pituitary in the Rat Hypothalamo-Posterior Pituitary System
- Relationship between Nitric Oxide Synthase and Heme Oxygenase-2 in the Canine Esophagus
- Astroglial Elements in the Suprachiasmatic Nucleus of the Golden Hamster and the Rat : Comparative Morphological Study Using Immunocytochemistry
- Succinate Dehydrogenase Activity of Motoneurons in the Retrodorsolateral Region of the Ventral Horn in the Rat Spinal Cord
- Colchicine, a Microtubule Depolymerizing Agent, Inhibits Myocardial Apoptosis in Rats
- PE-442 C-Reactive Protein Predicts Recurrence of Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-441 Relationship between Matrix Metalloproteinases and Late Gadolinium-Enhancement with Cardiovascular Magnetic Resonance in Patients with Nonischemic Dilated Cardiomyopathy(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The
- PJ-036 Usefulness of QRS Template Matching in Radiofrequency Catheter Ablation of Idiopathic Right Ventricular Outflow Tract Tachycardia(Arrhythmia, therapy(23)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- Differential Expression of Prolactin Releasing Peptide and Tyrosine Hydroxylase in Fibers Derived from the Same Neurons in the Rat
- VIP-like Immunoreactive and Vasopressin-like Immunoreactive Neuronal Elements in the Suprachiasmatic Nucleus of Japanese Monkey (Macaca fuscata) : Light and Electron Microscopic Immunocytochemical Study(Prof. K Watanabe Memorial Article)
- OE-080 A Link between Matrix Metalloproteinases in the Coronary Sinus and Left Ventricular Performance in Patients with Nonischemic Dilated Cardiomyopathy(OE14,Heart Failure (Biomarker) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- PJ-516 Sex Differences in the Relationship between G-protein Beta3 Subunit Gene C825T Polymorphism and Cardiovascular Events in Patients with Dilated Cardiomyopathy(Heart failure, clinical(18)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting
- Functional retinal input stimulates expression of astroglial elements in the suprachiasmatic nucleus of postnatal developing rat
- Foot Hyperalgesia after Thoracic Burn Injury : Histochemical, Behavioral and Pharmacological Studies
- Tyrosine Hydroxylase and NADPH-Diaphorase in the Rat Nodose Ganglion : Colocalization and Central Projection
- P-34 Immunocytochemical studies of neural restrictive silencer factor NRSF/REST
- Morphological survey of Prolactin-releasing peptide and its receptor with special reference to their functional roles in the brain
- Cell Size and Succinate Dehydrogenase Activity of Different Types of Fibers in Different Regions of the Tibialis Anterior Muscle in Mice and Rats
- Morphological and Functional Roles of Macrophages and Postganglionic Sympathetic Fibers in Dorsal Root Ganglions of a Rat Neuropathic Pain Model
- Morphological Interactions between Glial Fibrillary Acidic Protein (GFAP)-like Immunoreactive Elements and Lutenizing Hormone Releasing Hormone (LHRH)-like Immunoreactive Nerve Endings in the Median Eminence of the Rat : Double Labeling Immunoelectron Mic
- Fracture Toughness Enhanced by Grain Boundary Shielding in Submicron-Grained Low Carbon Steel
- Three-Dimensional Observation of Dislocations by Electron Tomography in a Silicon Crystal
- Wrapped Alignment Marks for Fabrication of Interference/Diffraction Hot Electron Devices
- W/Cr/Au/SiO_2 Composite Alignment Mark for Fabrication of Interference/Diffraction Hot Electron Devices
- Nanostrueture Alignment for Hot Electron Interference/Diffraction Devices
- Ultrafine Fabrication Technique for Hot Electron Interference/Diffraction Devices
- Analysis of plasma protein in newborn rats treated with diethylstilbestrol by using rapid micro two-dimensional electrophoresis
- The Effect of Boron/Antimony on the Brittle-to-Ductile Transition in Silicon Single Crystals
- The Effect of Arsenic on the Brittle-to-Ductile Transition in Si Single Crystals
- HVEM characterization of crack tip dislocations in silicon crystals
- EFFECT OF PARAQUAT ON PLASMA FIBRONECTIN, SERUM FREE HYDROXYPROLINE, SERUM CERULOPLASMIN AND LUNG COLLAGEN CONTENT IN MONKEYS
- Millimeter-Wave Deflection Properties of Liquid Crystal Prism Cells With Stack-Layered Structure
- Decrease in CD4^+CD25^+ and CD8^+CD28^+ T cells in interstitial pneumonitis associated with rheumatic disease
- THE PATTERN OF ACTION OF BLENDED CHINESE TRADITIONAL MEDICINES TO GLUCOSE TOLERANCE CURVES IN GENETICALLY DIABETIC KK-CA^y MICE
- GLUCOSE TOLERANCE CURVES IN GENETICALLY DIABETIC KKCA^y MICE : THE PHARMACOKINETIC ANALYSIS FOR HUMPING EFFECT
- HVEM study of crack-tip dislocations in Si crystals prepared by FIB and twin-blade cutting method
- TEM/AFM Observation of Crack Tip Plasticity in Silicon Single Crystals
- Ontogeny of neuropsin mRNA expression in the mouse brain
- Brittle-Ductile Transition in Low Carbon Steel Deformed by the Accumulative Roll Bonding Process
- Fracture Toughness Evaluated by Indentation Methods and Its Relation to Surface Energy in Silicon Single Crystals
- HVEM/AFM Observation of Hinge-Type Plastic Zones Associated with Cracks in Silicon Crystals
- Optical imaging reveals cation-Cl^- cotransporter-mediated transient rapid decrease in intracellular Cl^- concentration induced by oxygen-glucose deprivation in rat neocortical slices
- PJ-623 Increased Static Pressure Promotes Collagen Gel Contraction by Cardiac Fibroblasts without Cell Proliferation(Cardiac Hypertrophy, Basic and Clinical 2 (M) : PJ104)(Poster Session (Japanese))
- ENDOSCOPIC NECROSECTOMY UNDER DIRECT VISION AFTER ENDOSCOPIC ULTRASOUND-GUIDED CYSTGASTROSTOMY FOR ORGANIZED PANCREATIC NECROSIS
- Kinetics of intraocular cytokines in the suppression of experimental autoimmune uveoretinitis by type I IFN
- P10-04 Changes Detected in Plasma Antiproteases in Paraquat Poisoned Rats Using Micro Two-Dimensional Electrophoretic Analysis
- Millimeter-Wave Transmission Properties of Nematic Liquid-Crystal Cells with a Grating-Patterned Electrode Structure
- Experimental and numerical studies on rock bed heat storage for room heating systems
- Simultaneous optical imaging of intracellular Cl^- in neurons in different layers of rat neocortical slices: advantages and limitations
- NOVEL AND EXTENSIVE ASPECTS OF PARAQUAT-INDUCED PULMONARY FIBROGENESIS : COMPARATIVE AND TIME-COURSE MICROARRAY ANALYSES IN FIBROGENIC AND NON-FIBROGENIC RATS
- Two cases of reactive hemophagocytic syndrome: a patient with adult-onset Still's disease and a patient with herpes zoster and autoimmune abnormalities
- Laminar Natural Convection Heat Transfer in an Air Filled Square Cavity with Two Insulated Baffles Attached to its Horizontal Walls
- Adaptive changes in human smooth pursuit eye movement