Magnesium Deficiency in Patients With Recent Myocardial Infarction and Provoked Coronary Artery Spasm
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概要
- 論文の詳細を見る
This study sought to clarify the relationship between magnesium (Mg) deficiency and coronary artery spasm provoked by pharmacologic agents in patients with a recent acute myocardial infarction (AMI). Twenty-three consecutive patients suffering from AMI were investigated with a Mg retention test (Mg:0.1 mmol/kg for 4h) in both the acute phase (within 1 week (3±2 days) of onset) and the subacute phase (3-4 weeks (24±6 days) of the onset). Early coronary arteriography was performed in all patients. Coronary stenosis in the infarct-related artery was less than 90% in all patients in the subacute phase. The spasm provocation test was performed in the subacute phase and coronary spasm was defined as transient subtotal or total occlusion in association with angina or electrocardiographic ST-segment deviation. Coronary artery spasm was provoked in only 13 of the 23 patients. Compared with the control subjects (12 patients without coronary artery disease or coronary spasm), the 24-h Mg retention was significantly higher in patients with AMI(acute phase:78±27%, subacute phase:66±32%, vs control:48±12%, p<0.05). In the subacute phase, the 24-h Mg retention decreased in patients without coronary spasm (43±26%), but a high level of Mg retention was still observed in patients with coronary spasm (84±25%). There was no difference in the serum concentrations of Mg, calcium and phosphorus between the 2 groups on both phases. In conclusion, both Mg deficiency and provoked coronary artery spasm were noted in more than half of the Japanese patients with a recent AMI, suggesting a close association between Mg deficiency and AMI.
- 社団法人日本循環器学会の論文
- 2001-06-20
著者
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SUZUKI Jun
Department of Health Care Chemistry, College of Environmental Health, Azabu University
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Watanabe Kouki
Uwashima City Hospital
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Watanabe Kouki
Department Of Biofunctional Science Faculty Of Agriculture And Life Science Hirosaki University
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SUEDA Shozo
Department of Internal Medicine, Ehime Prefectural Niihama Hospital
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Ohtani Takashi
Department of Cardiology, Ehime National Hospital
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Watanabe Koki
Uwashima City Hospital
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Fukuda Hiroshi
Department of Cardiology, Saiseikai Saijo Hospital
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Uraoka Tadao
Department of Cardiology, Kita Medical Association Hospital
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Saeki Hideyuki
Department of Cardiology, Saiseikai Saijo Hospital
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Ochi Takaaki
Department Of Cardiology Takanoko Hospital
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Sueda Shozo
Department Of Cardiology Saiseikai Saijo Hospital
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Sueda Shozo
Department Of Cardiology Ehime Prefectural Niihama Hospital
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Suzuki Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Uraoka Tadao
Department Of Cardiology Kita Medical Association Hospital
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Ochi Takaaki
The Second Department Of Internal Medicine Ehime University School Of Medicine
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Watanabe Koki
Saiseikai Matsuyama Hospital
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Fukuda Hiroshi
Department Of Anatomy Kobe University School Of Medicine
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Saeki Hideyuki
Department Of Cardiology Saiseikai Saijo Hospital
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Saeki Hideyuki
Department Of Cardiology Ehime Prefectural Imabari Hospital
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Watanabe Kouki
Department Of Cardiology Uwajima City Hospital
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Suzuki Jun
Department Of Cardiology Saiseikai Saijo Hospital
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Ohtani Takashi
Department Of Cardiology Ehime Hospital
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OHTANI Takashi
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
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