INVOLVEMENT OF GLUCOCORTICOID IN INSULIN-INDUCED ANGIOGENESIS OF ADJUVANT POUCH GRANULOMA IN DIABETIC MICE
スポンサーリンク
概要
- 論文の詳細を見る
The effects of insulin and glucocorticoid on granuloma formation and angiogenesis were studied using an adjuvant pouch in mice and a carrageenin pouch in rats. Carrageenin-induced granuloma formation was suppressed in the diabetic state induced by alloxan in rats. The suppression was restored by adrenalectomy. Corticosterone counteracted the restoration, whereas epinephrine did not, suggesting that the effects of adrenalectomy are due to the lack of adrenocortical hormones rather than epinephrine. The blood corticosterone levels in alloxan mice increased, following the increase of glucose level, to more than 20 μg/dl after 4 weeks. The increase of corticosterone levels disappeared after adrenalectomy. In the mouse adjuvant pouch, corticosterone dose-dependently decreased granuloma formation and angiogenesis. The values of these two parameters obtained with a dose of 20 μg/ pouch corticosterone agreed with those of the serum levels in diabetic mice. Insulin dose-dependently reversed the suppressed angiogenesis of 20 μg corticosterone-treated mice and the dose-response curve approximated the curve of alloxan-treated mice. The effects of diabetes were concluded to involve insulin deficiency as well as glucocorticoid enhancement and the counteraction between the two may control granuloma formation and angiogenesis.
- 社団法人日本薬学会の論文
著者
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Yamada T
Univ. Tokyo Tokyo Jpn
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SUZUKI Jun
Department of Health Care Chemistry, College of Environmental Health, Azabu University
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Kimura M
Health Science Center At San Antonio The University Of Texas
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Suzuki Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Kimura M
Tsumura & Co. Ltd. Ibaraki Jpn
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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AMEMIYA KOUJI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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YAMADA TADASHI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Amemiya Kouji
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Suzuki J
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Suzuki Jun
Department Of Cardiology Saiseikai Saijo Hospital
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