HYPERSENSITIVITY OF ACETYLCHOLINE RECEPTOR IN DIABETIC SKELETAL MUSCLE TO NEUROMUSCULAR BLOCKERS : THE EFFECT ON MYOTUBES CULTURED WITH SPINAL CORD OR ITS EXTRACT
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概要
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The hypersensitivity of the neuromuscular junctions of diabetic mice to succinyl-choline (SuCh), but not to d-tubocurarine (d-TC), was investigated using a cross culture preparation of diabetic skeletal muscle or spinal cord extract with normal tissues. Whether the hypersensitivity is due to the muscle cells themselves was examined using adult muscle of diabetic KK-CA^y, prediabetic KK-CA^y and normal ddY mice cocultured with embryonic spinal cord of normal ddY mice. The cultured neuromuscular junctions between diabetic KK-CA^y muscle and normal ddY spinal cord was hypersensitive to SuCh, but not to d-TC. In contrast, such junctions between prediabetic KK-CA^y muscle and normal ddY spinal cord were not hypersensitive to either drug. The involvement of neuronal factors in hypersensitivity to SuCh in diabetic KK-CA^y neuromuscular junctions was examined using adult spinal cord extract (SCE) from diabetic KK-CA^y and from normal ddY mice. We followed the time course of change in sensitivity of the acetylcholine (ACh) receptors in normal ddY embryonic myotubes to SuCh and d-TC. Both diabetic SCE and normal SCE reduced the sensitivity of myotubes to ACh ; the reduction of ACh potential amplitudes by the former was less than that by the latter. Myotubes cultured with diabetic SCE was hypersensitive to both 1.51 μM SuCh and 0.134 μM d-TC. These results suggest that the hypersensitivity of the neuromuscular junctions in diabetic KK-CA^y mice to SuCh but not to d-TC is mainly attributable to the diabetic muscle cells. themselves.
- 公益社団法人日本薬学会の論文
著者
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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KIMURA Ikuko
Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu
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Kimura M
Health Science Center At San Antonio The University Of Texas
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Fukuta Mizuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Fukuta Mizuki
北陸大学 薬 薬理
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Inaba Kazuhiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Inaba Kazuhiko
北陸大学 薬 薬理
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura I
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura M
Tsumura & Co. Ltd. Ibaraki Jpn
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Kimura M
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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FUJIHARA MITSUHIRO
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Nojima Hiroshi
Faculty Of Horticulture Chiba University
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Nojima Hiroshi
Department Of Molecular Generics Research Institute For Microbial Diseases Osaka University
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Fujihara Mitsuhiro
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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