Potent Reduction of Intraocular Pressure by Nipradilol Plus Latanoprost in Ocular Hypertensive Rabbits(Pharmacology)
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概要
- 論文の詳細を見る
The present study was performed to evaluate the intraocular pressure (IOP)-lowering effect of nipradilol in combination with latanoprost on ocular normotensive and hypertensive rabbits. IOP was measured using an applanation pneumatonograph under topical application of 0.4% oxybuprocaine hydrochloride for corneal anesthesia. Ocular hypertension was induced by injection of 0.1 ml hypertonic saline (5% NaCl) into the vitreous body. Saline, nipradilol, latanoprost, sodium nitroprusside (SNP) or indomethacin was then instilled just after 5% NaCl injection. All drugs were instilled in the inferior conjunctival sac, using 50 μl drops. If more than two drugs were used, they were applied 5 min apart. Nipradilol lowered IOP in both ocular normotensive rabbits and ocular hypertensive rabbits, whereas latanoprost did not lower IOP in either. When nipradilol was applied in combination with latanoprost, the reduction in ocular hypertension was significantly enhanced, compared to the effect of nipradilol alone. A significantly potent reduction in ocular hypertension was also observed by the SNP-latanoprost combination. The IOP-lowering effects of SNP in combination with latanoprost were abolished by treatment with indomethacin. These results indicate that the IOP-lowering effect of latanoprost was enhanced when applied in combination with nipradilol or SNP, both of which have nitric oxide (NO)-donating actions. Since both combined effects were abolished by treatment with indomethacin, the mechanisms by which nipradilol combined with latanoprost lowered ocular hypertension may be related, at least in part, to the production of prostaglandins via the NO-donating action of nipradilol.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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木村 郁子
富山医薬大薬薬品作用学
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木村 郁子
富山医科薬科大学
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木村 郁子
富山医科薬科大学 臨床薬理学
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KIMURA Ikuko
Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu
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TSUNEKI Hiroshi
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University
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Inaba Kazuhiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Inaba Kazuhiko
北陸大学 薬 薬理
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Kimura I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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木村 郁子
富山医科薬科大学 薬学部 薬品作用学
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Tsuneki H
Department Of Clinical Pharmacology University Of Toyama
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ORIHASHI Masahiro
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and
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SHIMA Yuichiro
Teika Pharmaceutical Company
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木村 郁子
Department Of Clinical Pharmacology Graduate School Of Pharmaceutical Sciences Toyama Medical And Ph
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Tsuneki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Tsuneki Hiroshi
富山医科薬科大学大学院薬学研究科 臨床薬理学講座
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Orihashi Masahiro
Department Of Clinical Pharmacology Graduate School Of Pharmaceutical Sciences Toyama Medical And Ph
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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木村 郁子
Department of Food and Nutrition Science, Toyama College
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木村 郁子
富山医科薬科大学大学院薬学研究科 臨床薬理学講座
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TSUNEKI Hiroshi
Department of Clinical Pharmacology,Graduate School of Pharmaceutical Sciences,Toyama Medical and Pharmaceutical
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