Immunocytochemical Localization of Salivary Peptide P-C in Human Submandibular Gland
スポンサーリンク
概要
- 論文の詳細を見る
Human saliva contains a proline-rich polypeptide, salivary peptide P-C, which potentiates insulin release and reduces glucagon release from perfused rat pancreas to decrease blood glucose level. To elucidate the process of secretion into humoral fluid of this peptide morphologically, we investigated ultrastructural localization of P-C in human submandibular gland by immunogold technique with anti-peptide P-C whose specificity to P-C was confirmed by immunoblotting. The labeling with gold particles which represents the distribution of P-C-like-immunoreactivity (P-C-LI) was detected in the secretory granules and rough endoplasmic reticula of the acinar serous cells and in few mucosa cells. P-C-LI was also observed in the lumen of striated duct but not intracellularly in the ductal cells themselves, indicating the P-C is not probably reabsorbed there. These results suggest that salivary peptide P-C is present in acinar serous cells, is secreted into the oral cavity, and may be reabsorbed through the digestive tract to modulate the blood glucose level after feeding.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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KIMURA Ikuko
Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu
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TSUNEKI Hiroshi
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University
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Furuta Isao
Department Of Oral & Maxillofacial Surgery Toyama Medical & Pharmaceutical Univ.
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Furuta Isao
Department Of Oral And Maxillo-facial Surgery Faculty Of Medicine Toyama Medical And Pharmaceutical
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SASAMURA Takashi
Department of Applied Pharmacology, Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceut
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Sasamura Takashi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Sasamura Takashi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutic
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Iwai Masayuki
Department Of Oral And Maxillo-facial Surgery Faculty Of Medicine Toyama Medical And Pharmaceutical
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SASAMOTO Hidehiko
Diagnosics Research Department, Teikoku Hormone Mfg.
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FURUSAWA Yoshio
Natural Products Research Department, Teikoku Hormone Mfg.
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Tsuneki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Iwai Masayuki
Department Of Informatics And Electronic The University Of Tokyo:institute Of Industrial Science The
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Furusawa Y
Natural Products Research Department Teikoku Hormone Mfg.
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Tsuneki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Sasamoto Hidehiko
Diagnosics Research Department Teikoku Hormone Mfg.
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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