THE MODE OF ACTION OF CONTRACTILE EFFECTS INDUCED BY EXTERNAL CALCIUM AND ITS RELATED BIVALENT CATIONS IN THE KCl-DEPOLARIZED RAT UTERUS
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概要
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The cumulative log dose-response curve (DRC) isometrically produced by CaCl<SUB>2</SUB> on depolarized uteri of rats in Ca<SUP>2+</SUP>-free KCl Ringers solution (pH 7.8) showed a plateau-shaped type, when responses were plotted as a percent of the maximal tension of 50 μM acetylcholine, whereas those produced by BaCl<SUB>2</SUB> or SrCl<SUB>2</SUB> were a simple sigmoid type with the maximal response near the height of the plateau induced by Ca<SUP>2+</SUP>. The plateau phase of Ca<SUP>2+</SUP> was inhibited competitively by Mg2+ (0.5-50 mM) and non-competitively by Mn2+ (30 μM-1 mM), whereas the maximal contraction of Ca<SUP>2+</SUP> was not inhibited by either ion. Dantrolene (0.1 mM) inhibited both the plateau and the maximal contraction of Ca<SUP>2+</SUP> and retained the plateau-shaped type. EGTA (2 mM) potentiated the plateau to the maximal response level and changed the DRC induced by Ca<SUP>2+</SUP> to the simple sigmoid type. From these results, the plateau of DRC induced by Ca<SUP>2+</SUP> seems to be mainly due to actions of external Ca<SUP>2+</SUP> on the calcium binding of internal surface of cell membrane, suggesting that the internal surface is the site of action of the bivalent cations tested.
- 社団法人 日本薬理学会の論文
著者
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MAEKAWA Mutsuko
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Maekawa Mutsuko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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MAEKAWA Mutsuko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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