DIFFERENCE BETWEEN ADRENERGIC β<SUB>1</SUB>- AND β<SUB>2</SUB>-BLOCKING EFFECTS ON ISOPROTERENOL-INDUCED Ca SPIKE SUPPRESSION IN GUINEA-PIG TAENIA COLI
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概要
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Ca spike suppressions induced by isoproterenol (IsP) and a β<SUB>2</SUB>-agonist, 5-hydroxymethyl-6-hydroxy-2-isopropylamino-1, 2, 3, 4-tetrahydronaphthalene-1-ol (AA497), were investigated in the presence of butoxamine or practolol. The relaxations were isotonically recorded, and the Ca spike frequency was recorded using the single sucrose gap method. IsP-induced relaxation was not inhibited by butoxamine (Butox, 0.16 μM), but was inhibited by practolol (Prac, 0.188 μM). In 24 mM K<SUP>+</SUP>-Krebs solution, AA497 caused relaxation in a lower dose range and suppressed to a small extent the Ca spike frequency in a higher dose range, as was observed for IsP-induced curves of log dose-spike frequency and log dose-relaxation. In normal K<SUP>+</SUP>-Krebs solution, both IsP and AA497 greatly suppressed the Ca spike frequency. IsP (1.21 μM)-induced suppression of the Ca spike frequency was blocked by Prac (113 μM), and it was blocked by Butox (96 μM) to a greater extent. AA497-induced suppression of the spikes was not blocked by Prac (37.6 μM), but completely blocked by Butox (32 μM). These selective inhibitory effects of butoxamine on AA497-induced and IsP-induced Ca spike suppression demonstrate that in the adrenergic β-receptor-mediated process in taenia coli, β<SUB>2</SUB>-mechanisms are more closely related to the Ca spike suppression than the β<SUB>1</SUB>-mechanisms are.
- 社団法人 日本薬理学会の論文
著者
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Katoh Hiroshi
Department of Cardiovascular Medicine, Tohoku Rosai Hospital
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Katoh Hiroshi
Department Of Cardiology Katta General Hospital
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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KIMURA Masayasu
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KATOH Hiroshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KATOH Hiroshi
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University
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