INHIBITION OF COMPOUND 48/80-MEDIATED HISTAMINE RELEASE FROM ISOLATED RAT MAST CELLS BY OOSPONOL-RELATED COMPOUNDS (4-ACYL-ISOCOUMARINS)
スポンサーリンク
概要
- 論文の詳細を見る
Oosponol (4-hydroxymethylketone-8-hydroxyisocoumarin) is a metabolic product isolated from <I>Oospora astringens</I> which originated from house dust in a room of an asthmatic patient. The compound and the structurally related isocoumarins were studied to determine the inhibition of histamine release induced by compound 48/80 from isolated rat peritoneal mast cells. The released histamine was assayed by fluorometry. The compounds tested were not observed to release histamine. Some of 4-acyl-isocoumarins inhibited the histamine release at doses less than 10 μM, whereas the 3-acyl and the 4-alkyl-compounds were not effective at doses over 100 μM. The pretreatment of mast cell with the compound for 15 min before the application of compound 48/80 was more effective than the simultaneous administration. The mode of inhibitory action of KIT-302, 4-(4-carboxy-benzoyl)-isocoumarin, was non-competitive antagonism to compound 48/80 on the mast cells.
- 社団法人 日本薬理学会の論文
著者
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Kokubo Masaya
Department Of Chemistry School Of Science The University Of Tokyo
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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KOKUBO Masaya
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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