PHARMACOLOGICAL SEQUENTIAL TRIALS FOR THE FRACTIONATION OF COMPONENTS WITH HYPOGLYCEMIC ACTIVITY IN ALLOXAN DIABETIC MICE FROM GINSENG RADIX
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概要
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Three methods of fractionation of ginseng radix (Panax ginseng C. A. MEYER) components for a survey of hypoglycemic principle in alloxan diabetic mice were conducted and three groups of components tested ; fat-soluble components, ginseng saponins and a third component with hypoglycemic activity. Pharmacological sequential trials of the fractionation yielded a most active fraction which was about 100-fold more effective than the original water-soluble extract of the ginseng radix. The ED_<50> value was 0.4 mg/kg in lowering the blood level of glucose in alloxan diabetic mice. It was demonstrated that some ginseng fractions inhibited epinephrine-induced transient hyperglycemia in mice, increased glycogen content in rat liver, decreased the blood level of acetone bodies in alloxan diabetic mice, and inhibited the release of free fatty acid from rat epididymal fat pad. The results showed that hypoglycemic components existed in a new component of ginseng radix which is different from saponin.
- 公益社団法人日本薬学会の論文
著者
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TANAKA Osamu
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Kimura Masayasu
Toyama Medical And Pharmaceutical University
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Shibata Shoji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Shibata Shoji
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)meiji College Of Pharmacy
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Nagai Yumiko
Faculty Of Pharmaceutical Sciences University Of Tokyo
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WAKI ISAMI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Nagai Yumiko
Faculty Of Home Economics Jissen Wemen's University
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Tanaka Osamu
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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TANAKA Osamu
Institute for the Solid State Physics, University of Tokyo
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