EFFECTS OF A HYPOGLYCEMIC COMPONENT OF GINSENG RADIX ON INSULIN BIOSYNTHESIS IN NORMAL AND DIABETIC ANIMALS
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概要
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DPG-3-2,a component of ginseng radix, which lowers the blood glucose level and stimulates insulin release in diabetic animals, was studied for its effects on insulin biosynthesis in different preparations of pancreas from animals with normoglycemia and with hyperglycemia (alloxan diabetic rats and genetically diabetic mice, KK-CA^y). We measured incorporation of radioactive leucine into insulin and other protein fractions during a 2-h perfusion of rat pancreas, and into insulin during a 3-h incubation of mouse islets. Biosynthesis of insulin during a long-term culture of islets from KK-CA^y mice was also measured. DPG-3-2 was found practically not to increase the incorporation into insulin in the pancreatic preparations from animals with normoglycemia, but in such preparations from animals with hyperglycemia DPG-3-2 (0.2-1.0 mg/ml caused 1.5-1.8-fold incorporation into insulin. In addition, a long-term treatment of DPG-3-2 (0.5 mg/ml) was shown to stimulate insulin biosyntesis in islets from KK-CA^y mice. Ginsenoside-Rb_1 and -Rg_1 decreased the insulin content of islet to the undetectable level. Thus, DPG-3-2 was shown to stimulate insulin biosynthesis in different preparations of pancreas from animals with hyperglycemia.
- 公益社団法人日本薬学会の論文
著者
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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WAKI ISAMI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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KYO HITONOBU
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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YASUDA MASATOSHI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Kyo Hitonobu
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Yasuda Masatoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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