Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse.

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概要

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• The combined effects of paeoniflorin (PF), a main component of paeony roots, and glycyrrhizin (GLR), a main component of licorice roots, were investigated on isolated sciatic nerve-sartorius muscle preparations in frogs, or on isolated or <SUP>in situ</SUP> phrenic nerve-diaphragm muscle preparations in mice, intending to explain the effects of "Shakuyaku-Kanzô-Tô, composed of both these Chinese drugs, on clinical neuropathy. PF and GLR used together blocked indirectly stimulated twitchings at concentrations which when used alone induced no blocking effects. PF and GLR at a combining ratio of 1:2 (weight concentrations) corresponding to the amounts contained in "Shakuyaku-Kanzô-Tô, was more potent than when they were used at the ratio of 1:1 or 2:1. The synergistic effects induced by GLR were also confirmed for the other components, paeoniflorigenone or oxypaeoniflorin, which are contained in paeony roots, and for succinylcholine. The blocking effect of d-tubocurarine were not increased by GLR. Concludedly, PF and GLR were found to cause the pharmacological blend effect. The two combined compounds were mainly therapeutic components in "Shakuyaku-Kanzô-Tô".

• 公益社団法人 日本薬理学会の論文

著者

• Takahashi Kazuyoshi

  Department Of Cardiology Niigata City General Hospital

• Muroi Masashi

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Kimura Masayasu

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti

• Kimura Ikuko

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• KIMURA Masayasu

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• KITAGAWA Isao

  Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Osaka University

• YOSHIZAKI Masao

  Institute of Herbary, Toyama Medical and Pharmaceutical University

• KANAOKA Matao

  Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

• TAKAHASHI Kazuyoshi

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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