Th1/Th2 Balance Alteration in the Clinical Course of a Patient With Acute Viral Myocarditis
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概要
- 論文の詳細を見る
Cytokines have an important role in the pathogenesis and pathophysiology of myocarditis. In this study, subsets of peripheral helper T lymphocytes(Th)in a patient with acute viral myocarditis were analyzed by 3-color flow cytometry. During the clinical course of myocarditis, the Th1/Th2 ratio of peripheral lymphocytes changed. Th1 was dominant in the acute inflammatory phase during which levels of creatine kinase(CK)increased(day 6), then Th2 levels overtook those of Th1 in the recovery phase during which levels of CK decreased(day 13 and 20). At the time of discharge(day 35), Th1 and Th2 had normalized. Thus, it was speculated that the induction of lymphocytic myocarditis was associated with Th1 dominant status, and recovery was related to Th2 polarity. Th subset imbalances may play an important role in the pathogenesis of acute viral myocarditis and these analyses may be useful for understanding the disease activity of myocarditis.
- 社団法人日本循環器学会の論文
- 2001-11-20
著者
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ODA Hirotaka
Department of Cardiology, Niigata City General Hospital
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TAKAHASHI Kazuyoshi
Department of Cardiology, Niigata City General Hospital
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MIIDA Tsutomu
Department of Cardiology, Niigata City General Hospital
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Higuma Norio
Department of Cardiology, Niigata City General Hospital
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Aizawa Yoshifusa
the First Department of Internal Medicine
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Kodama Makoto
the First Department of Internal Medicine, Niigata University School of Medicine
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Oda Hirotaka
Niigata City General Hospital
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Tamura Yusuke
1st. Department Of Internal Medicine Niigata University School Of Medicine
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Oda Hirotaka
Department Of Cardiology Niigata City General Hospital
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Takahashi Kazuyoshi
Department Of Cardiology Niigata City General Hospital
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Tanabe Yasutaka
Department 1st Internal Medicine, Niigata University School of Medicine
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Yamaura Masayuki
Department Of Cardiology Niigata City General Hospital
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Fuse Koichi
Cardiovascular Center Tachikawa General Hospital
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Fuse Koichi
新潟大学 医学部第一内科
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Murakawa Yuji
The Second Department Of Internal Medicine. Faculty Of Medicine University Of Tokyo
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Tsuchida Keiichi
Department Of Cardiology Niigata City General Hospital
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Oda Hirotaka
Niigata Kobari Hospital
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Tanabe Yasuhiko
Department Of Internal Medicine Niigata Prefectural Shibata Hospital
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Toba Ken
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
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Higuma Norio
The Department Of Cardiology Niigata City General Hospital
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Higuma Norio
Department Of Cardiology Niigata City General Hospital
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Miida Tsutomu
Department Of Cardiology Niigata City General Hospital
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Yamazoe Masaru
Niigata City General Hospital
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Yamazoe Masaru
First Department Of Internal Medicine
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Sakai Katsuyuki
The Department of Cardiology, Niigata City General Hospital
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Sakai Katsuyuki
Department of Cardiology, Niigata City General Hospital
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Fuse Koichi
The First Department of Internal Medicine, Niigata University School of Medicine
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Kuroha Takashi
Division Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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Tanabe Yasutaka
Department Of Cardiology Niigata City General Hospital
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Ohtsuka Hideaki
Cardiovascular Center Tachikawa General Hospital
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Yamazoe Masaru
First Department Of Medicine Niigata University
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Tanabe Yasutaka
First Department Of Internal Medicine Niigata University School Of Medicine
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Yamaura Masayuki
Department Of Cardio-angiology Kitasato University School Of Medicine
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Makiyama Yashiro
Niigata City General Hospital
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Sakai Katsuyuki
The Department Of Cardiology Niigata City General Hospital
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Murakami Yuji
The Second Department Of Internal Medicine. Faculty Of Medicine University Of Tokyo
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Aizawa Yoshifusa
The First Department Of Internal Madicine Niigata University School Of Medicine
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