Levels of Serum Interleukin-10 Reflect Disease Activity in Patients With Cardiac Sarcoidosis
スポンサーリンク
概要
- 論文の詳細を見る
Cardiac involvement is the major determinant of morbidity and mortality in patients with sarcoidosis, but clinical evaluation of the disease activity is occasionally difficult in cardiac sarcoidosis. The present study examined whether serum levels of interleukin-10 (IL-10) could reflect the disease activity of patients with cardiac sarcoidosis. Serum IL-10 levels were measured using an enzyme-linked immunosorbent assay, and compared with clinical manifestation, levels of angiotensin-converting enzyme (ACE), levels of lysozyme and accumulation of gallium-67 citrate. Sera were collected from 8 patients with cardiac sarcoidosis (CS group), 22 patients with miscellaneous heart diseases except for sarcoidosis (MHD group), and 8 healthy control subjects (HC group). Serum IL-10 levels of the CS group were significantly higher than those of the 2 control groups. Before steroid therapy, the levels of IL-10 in the CS group showed a significantly positive correlation with levels of ACE (r=0.868, p<0.05) and lysozyme (r=0.890, p<0.05). In 5 patients who were analyzed before and after steroid therapy, the levels of IL-10 tended to correlate with a decrease of an abnormal accumulation in gallium-67 citrate. Serum IL-10 levels may play a role in evaluation of the disease activity in patients with cardiac sarcoidosis.
- 社団法人日本循環器学会の論文
- 2000-09-20
著者
-
Kato Kiminori
Niigata Association of Occupational Health
-
Aizawa Yoshifusa
the First Department of Internal Medicine
-
Ito Masahiro
the First Department of Internal Medicine, Niigata University School of Medicine
-
Kodama Makoto
the First Department of Internal Medicine, Niigata University School of Medicine
-
Fuse Koichi
Cardiovascular Center Tachikawa General Hospital
-
Fuse Koichi
新潟大学 医学部第一内科
-
Ohkura Yuji
新潟大学 医歯学総合研究科循環器学分野
-
Hirono Satoru
First Department Of Medicine Niigata University School Of Medicine
-
Sato Hironori
1st Dept. Of Med. Niigata Univ. School Of Med.
-
Hanawa H
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
-
Fuse Koichi
The First Department of Internal Medicine, Niigata University School of Medicine
-
Okura Yuji
The First Department of Internal Medicine, Niigata University School of Medicine
-
Aoki Yoshinori
The First Department of Internal Medicine, Niigata University School of Medicine
-
Hirono Satoru
The First Department of Internal Medicine, Niigata University School of Medicine
-
Kato Kiminori
The First Department of Internal Medicine, Niigata University School of Medicine
-
Hanawa Haruo
The First Department of Internal Medicine, Niigata University School of Medicine
-
Aoki Yoshinori
The First Department Of Internal Medicine Niigata University School Of Medicine
-
Hirono Satoru
Division Of Cardiology Niigata University School Of Medical And Dental Sciences
-
Aizawa Yoshifusa
The First Department Of Internal Madicine Niigata University School Of Medicine
関連論文
- PJ-474 The Effects of Erythropoietin-derivatives on Monocrotaline-induced Pulmonary Hypertension in Rats(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-366 Phase I/II Clinical Study of Angiogenic Therapy by Ex-Vivo Expanded Erythroblast Transplantation (EVEETA) for the Patients with Critical Limb Ischemia(PJ062,Regeneration (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Mee
- OJ-093 Appropriate Cutoff Value of Waist Circumference is Influenced by Age and BMI : Analysis of 68,785 Adults in Health-check Examination(OJ16,Metabolic Syndrome (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circula
- OJ-093 Appropriate Cutoff Value of Waist Circumference is Influenced by Age and BMI : Analysis of 68,785 Adults in Health-check Examination(OJ16,Metabolic Syndrome (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circula
- PJ-724 Asialoerythropoietin showed cardioprotective effects on ischemia-reperfusion injury model in mouse(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
- PJ-169 Intravenous erythropoietin administration attenuated monocrotaline-induced rat pulmonary hypertension(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-122 Ex Vivo Expanded Erythroblast-Transplantation (Autologous) Therapy, EVEETA, a Novel Remedy for Severe Limb Ischemia.(Regeneration(angiogenesis / myocardial regeneration)(02)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the
- Characterization of Outpatients With Isolated Diastolic Dysfunction and Evaluation of the Burden in a Japanese Community : Sado Heart Failure Study
- Prominent Systolic Coronary Flow in a Coronary Artery Fistula with a Giant Aneurysma
- Rupture of a Giant Saccular Aneurysm of Coronary Arteriovenous Fistulas
- Decrease of Nitric Oxide End-products during Coronary Circulation Reflects Elevated Basal Coronary Artery Tone in Patients with Vasospastic Angina
- Clinical Application of Bone Marrow Implantation in Patients With Arteriosclerosis Obliterans, and the Association Between Efficacy and the Number of Implanted Bone Marrow Cells
- PJ-284 Effect of Nicorandil on Arterial Wall Stiffness in Patients with Ischemic Heart Disease(Atherosclerosis, Clinical 3 (IHD) : PJ48)(Poster Session (Japanese))
- Thromboangitis Obliterance (TAO) in Niigata (Three Years Cohort Study)
- Primary Concerns during Daily Life in Patients with ICD and their Families (Role of ICD Discharge for Quality of Life)
- Comparison of triggering modes and therapeutic effect of nicorandil for ventricular tachyarrhythmia in canine models of LQT2 and LQT3
- Tridimensional analysis of onset mode and arrhythmogenesis of discordant QT/T alternans in long QT syndrome
- Discrepancy between Inducibility of Ventricular Tachycardia and Activity of Cardiac Sarcoidosis - Requirement of Defibrillator Implantation for the Inactive Stage of Cardiac Sarcoidosis -
- Role of α_1-Blockade in Congenital Long QT Syndrome : Investigation by Exercise Stress Test
- Fenofibrate, a Peroxisome Proliferator-Activated Receptor α Activator, Suppresses Experimental Autoimmune Myocarditis by Stimulating the Interleukin-10 Pathway in Rats
- Characterization of Outpatients With Systolic Dysfunction in a Japanese Community by Total Enumeration : Sado Heart Failure Study
- PJ-213 Impact of Exercise Capacity on the Quality of Life in Patients with Diastolic Dysfunction : Niigata Sado Heart Failure Study(Heart failure, clinical-16 (M) PJ36,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanes
- PJ-061 Relation between Quality of Life and Clinical Parameters in Patients with Systolic Dysfunction Niigata Sado Heart Failure Study(Heart failure, clinical-19 (M) PJ11,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japa
- Left Atrial Appendage Dysfunction in Chronic Nonvalvular Atrial Fibrillation is Significantly Associated With an Elevated Level of Brain Natriuretic Peptide and a Prothrombotic State
- Lipoprotein(a), Left Atrial Appendage Function and Thromboembolic Risk in Patients With Chronic Nonvalvular Atrial Fibrillation
- Segmental Conduction Block in a Low-Voltage Area Suppressed Macro-Reentrant Ventricular Tachycardia after Surgical Repair of Tetralogy of Fallot
- Imatinib Mesilate Inhibits Neointimal Hyperplasia via Growth Inhibition of Vascular Smooth Muscle Cells in a Rat Model of Balloon Injury
- PJ-532 Cardiac Myocytes in Myocarditis Markedly Increase Gene Expression of Anti-angiogenic Protein Endostatin(Myocarditis, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-179 Asialoerythropoietin is a Hopeful Drug for Angiogenesis Therapy(Regeneration (angiogenesis / myocardial regeneration)-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-711 The Effect of Asialoerythropoietin on Angiogenesis(Regeneration (angionenesis/myocardial regeneration)-7 (M) PJ119,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-274 Factor Analysis for Predicting the Prognosis of Ischemic Limbs after Cell Therapy(Peripheral circulation-7 (H) PJ46,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Erythroid Cells Play a Central Role in Angio/vasculogenesis in Bone Marrow Implantation (Molecular Biology, Vascular 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Dramatic Increase of Pancreatitis Associated Protein(PAP) Expression in Cardiomyocytes in Acute Phase of Experimental Autoimmune Myocarditis (Myocarditis, Basic/Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Erythropoiesis Induced Angiogenesis In Vitro(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Left Ventricular Mechanical Restitution of Patients with Chronic Heart Failure(Heart Failure, Clinical 18 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-371 Enhancing Effect of Erythropoietin on Neovascularization by Implantation of Bone Marrow Cells in Vivo(Angiogenesis 3 (IHD) : PJ62)(Poster Session (Japanese))
- OJ-265 Erythropoiesis Induced Angiogenesis in Vitro(Angiogenesis 2 (M) : OJ31)(Oral Presentation (Japanese))
- OJ-184 Serum Erythropoietin Level Was a Sensitive Marker of Limb Ischemia Receiving Implantation of Bone Marrow Mononuclear Cells(Peripheral Circulation/Vascular Disease 1 (H) : OJ21)(Oral Presentation (Japanese))
- FR167653 improved the Progression of the Experimental Autoimmune Myocarditis by suppressing IL-1 β production
- Gene therapy on EAM with pCAGGS plasmid encoding SLPI/IgG_1Fc chimera
- 0327 Impact of death certificate revision on the determination of the cause(s) of sudden death of unknown etiology in young to middle-aged victums.
- Activity Immediately Before the Onset of Non-Fatal Myocardial Infarction and Sudden Cardiac Death
- DIFFERENT RESPONSE OF LEFT VENTRICULAR DIMENSIONS TO NITROGLYCERIN IN PATIENTS WITH ARTIFICIAL PACEMAKER : A POSSIBLE SIGNIFICANCE OF REFLEX TACHYCARDIA FOR THE REDUCTION OF LV CAVITY AFTER NITROGLYCERIN
- Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation : Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration
- Serum Hepcidin-20 is Elevated during the Acute Phase of Myocardial Infarction
- 2 Evaluation of the Prospective Observation of Erythropoietin-Administration for the Treatment of Acute Myocardial Infarction (EPO-AMI)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-236 "Reverse Epidemiology" in Japanese Patients with Chronic Heart Failure and Hypercholesterolemia (Niigata-Sado Heart Failure Study)(Heart failure, clinical-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-034 The Association Between the Type of Cardiac Dysfunction and Hospitalization Due to Congestive Heart Failure(Heart failure, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Elderly Patients with Systolic Dysfunction in the Community (Niigata-Sado Heart Failure Study) (Heart Failure, Clinical 16 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Approximate Prevalence of Diastolic Dysfunction in the Community (Niigata-Sado Heart Failure Study) (Heart Failure, Clinical 16 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Burden of Systolic and Diastolic Ventricular Dysfunction in the Community (Preventive Medicine/Epidemiology/Education/Health Policy 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- QT PROLONGATION IN ALCOHOLICS AND THE EFFECT OF ABSTINENCE
- Alteration of IL-17 Related Protein Expressions in Experimental Autoimmune Myocarditis and Inhibition of IL-17 by IL-10-Ig Fusion Gene Transfer
- PJ-007 Expression of Hepcidin Increases in Cardiomyocytes under Myocarditis and Myocardial Infarction(Acute myocardial infarction, basic(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-623 Long-Term Change of Renal Function in Japanese Patients with Idiopathic Dilated Cardiomyopathy(Heart failure, clinical-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-083 Mechanical Alternans is a Possible Linker between Heart Failure and Ventricular Fibrillation(Heart failure, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Optimal Cut-off Point of C-Reactive Protein as an Optional Component of Metabolic Syndrome in Japan
- PJ-204 Blood Pressure and Cardiovascular Events in the Outpatients with Systolic Dysfunction : Niigata Heart Failure Study(Heart failure, clinical-11 (M) PJ34,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circula
- PJ-065 An Epidemic of Systolic Heart Failure is being Realizing in an Urban Area in Japan Niigata-Sado Heart Failure Study(Heart failure, clinical-19 (M) PJ11,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Th1/Th2 Balance Alteration in the Clinical Course of a Patient With Acute Viral Myocarditis
- -0854- BACKGROUNDS OF MECHANICAL ALTERNANS IN PATIENTS WITH CHRONIC HEART FAILURE(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- THETAPY AGAINST RAT EXPERIMENTAL AUTOIMMUNE MYOCARDITIS WITH ANTK-αβT CELL RECEPTOR ANTIBODIES
- EXPERIMENTAL CHRONIC ACTIVE MYOCARDITIS LEADING TO DILATED CARDIOMYOPATHY
- A CASE OF VASOVAGAL SYNCOPE WITH CONVULSIONS : The Effects of Midodrine Hydrochloride
- CLINICAL CHARACTERISTICS AND POSSIBLE ROLE OF CORONARY ARTERY SPASM IN SYNCOPE AND/OR ABORTED SUDDEN DEATH
- -0902-ELECTROPHYSIOLOGIC ASSESSMENT OF SUSTAINED VENTRICULAR TACHYCARDIA ASSOCIATED WITH IDIOPATHIC DILATED CARDIOMYOPATHY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0901-ELECTROPHYSIOLOGICAL ABNORMALITIES AT THE REENTRANT CIRCUIT IN SUSTAINED VENTRICULAR TACHYCARDIA : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- AN ULTRASTRUCTURAL CHARACTERISTICS OF ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA WITH A SPECIAL REFERENCES TO LIPID DROPLETS IN THE CYTOPLASMA : Cardiac Pathology : 53 Annual Scientific Meeting, Japanese Circulation Society
- Severe Cryoglobulinemia in a Patient with Asymptomatic Hepatitis C Virus Infection
- Plasma Concentrations of Cytokines and Neurohumoral Factors in a Case of Fulminant Myocarditis Successfully Treated With Intravenous Immunoglobulin and Percutaneous Cardiopulmonary Support
- Systemic Th1/Th2 balance alteration regulates the clinical course of acute myocarditis
- Relation between mechanical alternans and ST-T electrical alternans in patients with chronic heart failure
- Changes in the Occurrence of Mechanical Alternans After Long-Term β-Blocker Therapy in Patients With Chronic Heart Failure
- Abnormal fatty acid matabolism in patients with coronary vasospasm
- Myocardial CD36 expression and fatty acid accumulation in patients with type I and II CD36 deficiency
- PJ-731 Parameters to Represent Impaired Force-frequency Relationship in Patients with Chronic Heart Failure(Cardiac function, basic/clinical-5 (M) PJ124,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- PJ-193 Relation between Mechanical Restitution Property and Left Ventricular Systolic Function in Patients with Chronic Heart Failure(Heart failure, basic-6 (M) PJ33,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- Levels of Serum Interleukin-10 Reflect Disease Activity in Patients With Cardiac Sarcoidosis
- Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
- Long-Term Outcomes of EP-Guided Sotalol Treatment for Sustained Ventricular Tachyarrhythmias
- Hydrodynamics-Based Delivery of an Interleukin-1 Receptor Antagonist-Ig Fusion Gene Ameliorates Experimental Autoimmune Myocarditis in Rats(The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A Novel Method to Assay Proteins in Blood Plasma after Intravenous Injection of Plasmid DNA
- Cardiac Fatty Acid Metabolism Was Impaired and Delayed in Peroxisome Proliferator Activated Receptor (PPAR) alpha-Null Mice
- Myocardial Intramitochondrial Beta-Oxidative Fatty Acid Metabolism Is Accelerating in Chronic Heart Failure
- Amiodarone Suppressed Left Ventricular Remodeling and Improved Cardiac Function and Sympathetic Function in Chronic Heart Failure after Autoimmune Myocarditis
- A Possible Crosstalk between Cardiomyocytes, Inflammatory and Non-inflammatory Interstitial Cells by Immunologic Molecules in Rat Experimental Autoimmune Myocarditis (Myocarditis, Basic/Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Ci
- Ischemic Heart Diseases with Systolic Dysfunction in the Community (Niigata-Sado Heart Failure Study)(Myocardial Ischemia-reperfusion, Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Cerebrovascular Diseases are an Independent Predictor of Death for Systolic Dysfunction Patients (Niigata-Sado Heart Failure Study)(Cerebrovascular Circulation/Stroke 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relation Between Renal Dysfunction and Heart Failure in the Community (Niigata-Sado Heart Failure Study)(Kidney/Renal Circulation 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Effect of Hydrodynamic-based Delivery of an Interleukin-13-Ig Fusion Gene for Experimental Autoimmune Myocarditis in Rats and Its Possible Mechanism(Gene Therapy 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-232 Linkage between Mechanical And Electrical Alternans in Patients with Chronic Heart Failure(Heart Failure, Clinical 3 (M) : PJ39)(Poster Session (Japanese))
- Characteristics of Cardiac Myocyte, Infiltrating Cells and Non-Myocate Cells in Experimental Autoimmune Myocarditis
- In Vitro Cytotoxic Activity of Heart-Infiltrating Cells in Experimental Autoimmune Myocarditis
- Localization of Coxsackievirus and Adenovirus Receptor (CAR) in Rat Heart
- Effect of gene transfer of cytotoxic T lymphocyte associated molecule 4 -lgG Fc chimera (CTLA4lg) by electroporation against experimental autoimmune myocarditis
- Eicosapentaenoic acid Improves Arterial Stiffness in Mild Cases of Diabetes Mellitus (Atherosclerosis, Clinical 12 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Successful Induction of β-blocker Therapy for a Patient with Peripartum Cardiomyopathy Complicated with Significant Aortic Stenosis
- Is n-3 Polyunsaturated Fatty Acids(PUFA)/n-6 PUFA the Risk Factor of Myocardial Infarction? : The Results of Case Control Study (Lipid Disorders 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-431 Increased in vivo Myocardial Uptake of Adenovirus in Rat Experimental Autoimmune Myocarditis(Myocarditis, basic/clinical-2 (M) PE72,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Single-Dose Intravenous Administration of Recombinant Human Erythropoietin Is a Promising Treatment for Patients With Acute Myocardial Infarction : Randomized Controlled Pilot Trial of EPO/AMI-1 Study