Decrease of Nitric Oxide End-products during Coronary Circulation Reflects Elevated Basal Coronary Artery Tone in Patients with Vasospastic Angina
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概要
- 論文の詳細を見る
The aim of this study was to investigate the role of nitric oxide (NO) in the coronary circulation and its relation to basal coronary artery tone in patients with vasospastic angina (VSA). We evaluated the level of nitric oxide end-products (NOx; nitrite + nitrate) in coronary circulation blood using an HPLC-Griess system for nine patients with VSA and nine control patients. All of the patients with VSA experienced focal spasm in the proximal to middle segments of the left anterior descending coronary artery (LAD) in response to intracoronary injection of ergonovine maleate. The luminal diameter of the coronary artery was measured in each patient by quantitative coronary arteriography. Blood samples for NOx measurement were obtained from the coronary sinus (NOxV) and the ostium of the left coronary artery (NOxA). The NOx difference, calculated from the coronary venous-arterial difference in NOx, was close to zero for the control patients whereas it was clearly negative for the patients with VSA. In addition, the NOx difference in the patients with VSA showed a negative correlation with basal coronary artery tone (r = - 0.91, p < 0.01) and a positive correlation with the dose of ergonovine required for spasm provocation (r = 0.77, p < 0.05). These results indicate that increased basal coronary artery tone and higher susceptibility to ergonovine in patients with VSA would be a consequence of coronary endothelial dysfunction as is indicated by NOx.
- Japanese Heart Journal Associationの論文
著者
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Hori Tomoyuki
the First Department of Internal Medicine
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Matsubara Taku
the First Department of Internal Medicine
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Aizawa Yoshifusa
the First Department of Internal Medicine
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Ishibashi Takaharu
Department of Pharmacology, Kanazawa Medical University
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Yamazoe Masaru
the First Department of Internal Medicine, Niigata University School of Medicine
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Ida Toru
the First Department of Internal Medicine, Niigata University School of Medicine
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Higuchi Kotaro
the First Department of Internal Medicine, Niigata University School of Medicine
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Takemoto Minoru
the First Department of Internal Medicine, Niigata University School of Medicine
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Ochiai Sachie
the First Department of Internal Medicine, Niigata University School of Medicine
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Tamura Yusuke
the First Department of Internal Medicine, Niigata University School of Medicine
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Nishio Matomo
Department of Pharmacology, Kanazawa Medical University
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Tamura Yusuke
新潟大学 医歯学総合研究科循環器学分野
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Yamazoe Masaru
The First Department Of Internal Medicine Niigata University School Of Medicine
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Nishio Matomo
Department Of Endocrinology Kanazawa Medical University
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Aizawa Yoshifusa
The First Department Of Internal Madicine Niigata University School Of Medicine
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HIGUCHI Kotaro
The First Department of Internal Medicine Niigata University
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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Matsubara Taku
the First Department of Internal Medicine, Niigata University School of Medicine
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