Effects on 4,4'-Diisothiocyanato-stilbene-2,2'-disulfonic Acid (DIDS) and Chlorpromazine on NO_3^- Transport via Anion Exchanger in Erythrocytes : Inertness of DIDS in Whole Blood
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effects of chlorpromazine on NO3− transport between erythrocytes (RBCs) and extracellular fluid. Chlorpromazine (10 μg/ml) did not influence NO3− movement in both whole blood and RBC suspension. Though an anion exchanger (AE1) inhibitor DIDS (4,4-diisothiocyanato-stilbene-2,2-disulfonic acid, 100 μM) did not alter NO3− movement in whole blood, it inhibited the movement in a concentration-dependent manner in the RBC suspension. The inhibition was abrogated by plasma and albumin concentration-dependently. Our results indicated that chlorpromazine had no effect on NO3− transport through AE1 and that the inertness of DIDS on AE1 in whole blood is due to interference by albumin in plasma.
- 社団法人 日本薬理学会の論文
- 2003-12-01
著者
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AIZAWA Yoshifusa
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences
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YOSHIDA Junko
Department of Pharmacology, Kanazawa Medical University
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Matsubara Taku
Division of Cardiology, Shinrakuen Hospital
-
Hori Tomoyuki
Division of Cardiology, Niigata University Graduate School of Medical & Dental Sciences
-
Ozaki Kazuyuki
Division of Cardiology, Niigata University Graduate School of Medical & Dental Sciences
-
Kubota Kaname
Division of Cardiology, Niigata University Graduate School of Medical & Dental Sciences
-
Ishibashi Takaharu
Department of Pharmacology, Kanazawa Medical University
-
Nishio Matomo
Department of Pharmacology, Kanazawa Medical University
-
Nishio Matomo
金沢医科大学 看護学部薬理学
-
Nishio M
Department Of Pharmacology School Of Medicine Kanazawa Medical University
-
Nishizawa M
Department Of Endocrinology Kanazawa Medical University
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Matsubara Taku
Shinrakuen Hospital
-
Matsubara T
Division Of Cardiology Shinrakuen Hospital
-
Matsubara Taku
新潟大学 医歯学総合研究科循環器学分野
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Ishibashi Takaharu
金沢医科大学 看護学部薬理学
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Ishibashi Takaharu
Pharmacology School Of Nursing Kanazawa Medical University:department Of Pharmacology School Of Medi
-
Ishii Takashi
Department Of Pharmacology Kanazawa Medical University
-
Ishibashi Takaharu
旭川医科大学 薬理
-
Hori Tomoyuki
新潟大学 医歯学総合研究科循環器学分野
-
Hori Tomoyuki
Divisions Of Cardiology
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Yamaura Masayuki
Department Of Cardiology Niigata City General Hospital
-
Murakawa Yuji
The Second Department Of Internal Medicine. Faculty Of Medicine University Of Tokyo
-
Matsubara Taku
First Department of Internal Medicine
-
Yoshida Junko
Department Of Pharmacology School Of Medicine Kanazawa Medical University
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YAMAZOE Masaru
Division of General Medicine, Niigata City General Hospital
-
Yoshida Junko
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
-
Ohtaki Keita
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
-
Matsubara T
First Department Of Internal Medicine Institute Of Nephrology Niigata University School Of Medicine
-
Matsubara Taku
Division Of Cardiology Shinrakuen Hospital
-
Yamazoe Masaru
Niigata City General Hospital
-
Yamazoe Masaru
First Department Of Internal Medicine
-
Kubota Kaname
The First Departiment of Internal Medicine,Niigata University School of Medicine
-
Ishibashi Takaharu
Department Of Pharmacology Asahikawa Medical College
-
Kubota Kaname
The First Departiment Of Internal Medicine Niigata University School Of Medicine
-
Yamazoe Masaru
First Department Of Medicine Niigata University
-
Nishizawa Makoto
Division Of Endocrinology Department Of Internal Medicine
-
Ozaki Kazuyuki
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
-
Makiyama Yashiro
Niigata City General Hospital
-
Aizawa Yoshifusa
Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M
-
Nishio Matomo
Department Of Endocrinology Kanazawa Medical University
-
Hori Tomoyuki
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
-
Murakami Yuji
The Second Department Of Internal Medicine. Faculty Of Medicine University Of Tokyo
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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