Comparative Analysis of Systolic and Isolated Diastolic Dysfunction : Sado Heart Failure Study

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概要

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• Determining the type of cardiac dysfunction is important for implementing therapeutic strategies and for prognostic insights. We characterized systolic dysfunction (SD) and isolated diastolic dysfunction (IDD) in adults referred for echocardiographic evaluation, and compared their clinical and other characteristics. In the present work, we studied 218 patients (137 males) with cardiac dysfunction (mean age, 66.3 ± 8.3 years). SD was defined as a left ventricular ejection fraction (LVEF) of < 45%, whereas IDD was defined as a LVEF ≥ 45% in addition to the standard Doppler-echocardiography diagnostic criteria for IDD. Approximately 68% of subjects had SD (70% males). The proportions of hypertension, diabetes, and dyslipidemia were 44%, 26%, and 22%, respectively, without significant association with the type of dysfunction. Myocardial infarction (MI) was found in 31% of patients, and was significantly (P < 0.001) more prevalent among SD compared with IDD cases. Cerebral stroke (18%) and malignancy (16%) were significantly associated with IDD (29% versus 13% for SD in the case of stroke, and 26% versus 11% for SD in the case of malignancy; P = 0.008 for each). In multivariately-adjusted logistic regression analysis, the following variables were found to be significantly (P < 0.05) and independently associated with IDD: female gender (odds ratio [OR] = 2.207 [95% CI = 1.302-4.608]), stroke (OR = 2.009 [1.119-3.980]), and malignancy (OR = 2.016 [1.230-4.010]). On the other hand, previous MI (OR = 2.075 [1.769-4.808]) was independently associated with SD. In conclusion, some factors/comorbidities were more likely to associate with IDD (female gender, stroke, and malignancy) or SD (previous MI) when IDD and SD were compared with each other.

著者

• AIZAWA Yoshifusa

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• HAO Kazuhisa

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• KODAMA Makoto

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Hoyano Makoto

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Okura Yuji

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Ramadan Mahmoud

  Division Of Cardiology First Department Of Internal Medicine

• Ohno Yukiko

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Suzuki Keisuke

  Sado General Hospital

• Taneda Koji

  Sado General Hospital

• Kimura Shinpei

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Hao Kazuhisa

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Kodama Makoto

  Division Of Cardiology Department Of Cardiovascular And Vital Control Niigata University Graduate Sc

• Ramadan Mahmoud

  Division Of Cardiology Department Of Internal Medicine Mansoura Faculty Of Medicine Mansoura Univers

• Kimura Shinpei

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science

• Aizawa Yoshifusa

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Ohno Yukiko

  Division Of Cardiology First Department Of Internal Medicine

• Hoyano Makoto

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Ramadan Mahmoud

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

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