Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation : J-RHYTHM Study(Arrhythmia/Electrophysiology)
スポンサーリンク
概要
- 論文の詳細を見る
Background Although previous clinical trials demonstrated the non-inferiority of a rate control to rhythm control strategy for management of atrial fibrillation (AF), the optimal treatment strategy for paroxysmal AF (PAF) remains unclear. Methods and Results A randomized, multicenter comparison of rate control vs rhythm control in Japanese patients with PAF (the Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM) study) was conducted. The primary endpoint was a composite of total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure, or physical/psychological disability requiring alteration of treatment strategy. In the study, 823 patients with PAF were followed for a mean period of 578 days. The primary endpoint occurred in 64 patients (15.3%) assigned to rhythm control and in 89 patients (22.0%) to rate control (P=0.0128). No significant differences between the treatment strategies were observed in the incidences of death, stroke, bleeding and heart failure. Meanwhile, significantly fewer patients requested changes of assigned treatment strategy in the rhythm control vs the rate control group, which was accompanied by improvement in AF-specific quality of life scores. Conclusion The J-RHYTHM study showed that rhythm control was associated with fewer primary endpoints than rate control. However, mortality and cardiovascular morbidity were not affected by the treatment strategy (umin-CTR No. C000000106).
- 社団法人日本循環器学会の論文
- 2009-01-20
著者
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AIZAWA Yoshifusa
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences
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NAKAYA Haruaki
Department of Pharmacology, Chiba University Graduate School of Medicine
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小川 聡
国際医療福祉大 三田病院
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Katoh Takao
1st Department Of Internal Medicine Nippon Medical School
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Shirao K
Department Of Cardiovascular Surgery National Cardiovascular Center
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Sakurai Masayuki
Hokko Memorial Hospital
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OGAWA Satoshi
Department of Regulation Biology, Faculty of Science, Saitama University
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Kodama Itsuo
Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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IIMURA Hiroyuki
The Cardiovascular Institute
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Iinuma Hiroyuki
The Cardiovascular Institute
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Kasai Satoshi
国立循環器病センター 心臓血管内科
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Inoue Hiroshi
富山大学附属病院 神経内科
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Inoue H
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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YAMASHITA Takeshi
The Cardiovascular Institute
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SUGI Kaoru
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Tanaka Keiji
武蔵野赤十字病院
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Okumura Ken
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of
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YAMAZAKI Tsutomu
University of Tokyo
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Inoue H
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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NAKAYA Haruaki
Chiba University
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FUKATANI Masahiko
Chikamori Hospital
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MITAMURA Hideo
Saiseikai Central Hospital
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Yamazaki Tsutomu
Clinical Epidemiology & Systems, University of Tokyo
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Atarashi Hirotsugu
Internal Medicine, Nippon Medical School Tama-Nagayama Hospital
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Inoue Hiroshi
2nd Department of Internal Medicine, University of Toyama
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Ohe Tohru
Cardiovascular Medicine, Okayama University
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Ohtsu Hiroshi
Clinical Epidemiology & Systems, University of Tokyo
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Okumura Ken
Cardiology, Hirosaki University
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Katoh Takao
Internal Medicine, Nippon Medical School
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Kamakura Shiro
Cardiovascular Medicine, National Cardiovascular Center
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Kumagai Koichiro
Cardiology, Fukuoka University
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Kurachi Yoshihisa
Department of Pharmacology II, Osaka University
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Koretsune Yukihiro
Inst. for Clinical Research, Osaka National Hospital
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Saikawa Tetsunori
Cardiovascular Science, Oita University
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Sakurai Masayuki
Department of Cardiology, Hokko Memorial Hospital
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Tabuchi Toshifumi
Tabuchi Naika
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Nakayama Toshio
Nakayama Clinic
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Hirai Makoto
Health Sciences, Nagoya University
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Mitamura Hideo
Cardiology, Saiseikai Central Hospital
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Ohara Takahiro
国立循環器病センター 心臓血管内科
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Sugi Kaoru
Division Of Cardiology Toho University
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Koretsune Yukihiro
Cardiovascular Division Osaka National Hospital
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Hara Motoki
Health Sciences Nagoya University
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Aizawa Y
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
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Mitamura H
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ohe T
Dep. Of Cardiovascular Medicine The Sakakibara Heart Inst. Of Okayama
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Ohe Tohru
Japanese Lqts Multicenter Registry By The Minister Of Health Lobour And Welfare National Cardiovascu
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Ohe Tohru
群馬県立心臓血管センター 循環器内科
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Ohtsu Hiroshi
Department Of Clinical Trial Data Management Graduate School Of Medicine University Of Tokyo
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Ohtsu Hiroshi
岩手医科大学 内科学第三
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Itoh Haruki
Department Of Cardiology Sakakibara Heart Institute
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Itoh Haruki
心臓血管研究所
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Atarashi Hirotsugu
Department Of Internal Medicine Nippon Medical School Tama-nagayama Hospital
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Ohe Tohru
Executive Committee for JALT-2 Study Group
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Kumazaki Tatsuo
Department Of Radiology And Center For Advanced Medical Technology Nippon Medical School
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相澤 好治
北里大学 医学部 衛生学公衆衛生学教室
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Iinuma Hiroyuki
鹿児島大学 大学院医歯学総合研究科循環器・呼吸器・代謝内科学
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Iinuma Hiroyuki
東京健生病院
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Kijima T
Department Of Cardiology Tokyo Women's Medical University
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Tanaka Keiji
Department Of Cardiology Tokyo Women's Medical University
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Ogawa Satoshi
Department Of Cardiology Keio University
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Ogawa S
Department Of Internal Medicine Keio University School Of Medicine
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Aizawa Yoshifusa
新潟大学 医学部保健学科
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Okamura Kazuki
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
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KUMAGAI Koichiro
Heart Rhythm Center, Fukuoka Sanno Hospital
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Mori H
国立病院機構岡山医療センター 循環器科
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Kumagai Koichiro
Heart Rhythm Center Fukuoka Sanno Hospital
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Kitamura Soichiro
National Cardiovascular Center
-
Mitamura Hideo
The NATIVE
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Sase Kazuhiro
Juntendo University Medical School
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Ohno Tetsuo
東京慈恵会医科大学 生理学第1
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Mitamura Hideo
Cardiology Saiseikai Central Hospital
-
Kitamura Souichiroh
国立循環器病センター 心臓血管内科
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Kato Takeshi
The First Department Of Internal Medicine Nippon Medical School
-
Okumura Ken
Division Of Cardiology Hirosaki University School Of Medicine
-
Matsubara Hiromi
Departments of Cardiovascular Medicine
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Ohe Tohru
Cardiovascular Medicine Okayama University
-
Ohe Tohru
岡山医療センター 循環器科
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Sugi Kaoru
Division Of Cardiovascular Medicine Toho University Ohashi Hospital
-
Itoh Haruki
Cardiovascular Institute
-
Kodama Itsuo
Research Institute For Environmental Medicine Nagoya University
-
Inoue H
Dept. Biotechnology Faculty Of Engineering Sciences
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
-
Nakaya Haruaki
Department Of Orthopaedic Surgery And Pharmacology School Of Medicine Chiba University
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Tanimoto Kyoumi
Division Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Kasai Satoshi
National Cardiovascular Center
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相澤 好治
北里大学・医・衛生公衛
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Ohe Toru
The Sakakibara Heart institute of Okayama
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Aizawa Yoshihusa
The First Department Of Internal Medicine Niigata University School Of Medicine Tachikawa Hospital T
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Mori Hidezo
The Native
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Tanaka Keiji
日本医科大学 集中治療室
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Itoh Haruki
Int. Medicine Yokosuka Mutual Aid Hospital.
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Matsuura Hiroshi
Dep. Of Physiology Shiga Univ. Of Medical Sci. Jpn
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Yoshikawa Tsutomu
University Of Tokyo
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Saikawa Tetsunori
Cardiovascular Science Oita University
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Kurachi Yoshihisa
Department Of Pharmacology Ii Osaka University
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Mitamura Hideo
Division Of Cardiology Tokyo Saiseikai Central Hospital
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Iinuma Hiroyuki
Second Department Of Internal Medicine University Of Toyama
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Yoshikawa Tsutomu
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Katagiri Takashi
The Third Department Of Internal Medicine Showa University School Of Medicine
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Tanizaki Kohei
Department Of Cardiology Heart Institute Of Japan Tokyo Women's Medical University
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Tanizaki Kohei
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Ogawa Satoshi
Department Of Anatomy And Neuroscience Osaka University Medical School
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Kitamura Soichiro
Department Of Cardiology National Cardiovascular Center
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Aizawa Yoshifusa
Cardiovascular Medicine Niigata University Graduate School Of Medicine
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Ohe Tohru
岡山大学 医歯薬学総合研究科循環器内科
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Ohe Tohru
Department Of Cardiovascular Surgery And Cardiology
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Katoh Takao
Division Of Cardiology Department Of Medicine Nippon Medical School
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Aizawa Yoshifusa
Division Of Cardiology Niigata University Graduate School Of Medicine And Dental Sciences
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Tokuyama Kenichi
Departments Of Intensive Care Unit Chiba Hokusoh Hospital Nippon Medical School
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Aizawa Y
新潟大学 内科
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Ohe Toru
Cardiovascular Medicine Okayama University
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Ohe Toru
Department Of Cardiology Okayama University
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Katoh Takao
First Dept Of Internal Medicine Nippon Medical School
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Kitamura Souichirou
Cardiovascular Division Of Internal Medicine National Cardiovascular Center
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Katagiri Takashi
Department Of Cardiology Kobe City Medical Center General Hospital
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Ohe Tohru
Cardiovascular Medicine Okayama University Medical School
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Kurachi Yoshihisa
Department Of Pharmacology Graduate School Of Medicine Osaka University
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Aizawa Yoshifusa
Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M
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Aizawa Yoshifusa
First Department Of Internal Medicine Niigata Universaity School Of Medicine
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Hirai Makoto
Health Sciences Nagoya University
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Ohe Tohru
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Aizawa Yoshifusa
Division Of Endocrinology And Metabolism Department Of Homeostatic Regulation And Developments Niiga
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Okumura Ken
Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of Medicine
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Ohe Tohru
Department Of Cardiovascular Surgery National Cardiovascular Center
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Ohe Toru
Cardiac Division Department Of Medicine National Cardiovascular Center Hospital
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Hiraoka Masayasu
Tokyo Medical And Dental University Medical Research Institute
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Kurachi Yoshihisa
Department Of Cell Biology And Signaling Yamagata University School Of Medicine:department Of Pharma
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Kitada Shuichi
Division Of Cardiology Department Of Medical National Cardiovascular Center
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Aizawa Yoshifusa
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical An
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Atarashi Hirotsugu
Internal Medicine Nippon Medical School Tama-nagayama Hospital
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Toba Ken
Division Of Hematology Niigata University Medical And Dental Hospital
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Hirai Makoto
J-rhythm Clinical Trial Center The Cardiovascular Institute
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Takahashi Yasuhiro
Division Of Cardiology Department Of Internal Medicine Nippon Medical School
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Kato Takao
Department Of Disease Control And Homeostasis Graduate School Of Medical Science Kanazawa University
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Mitamura Hideo
Cardiopulmonary Division Department Of Internal Medicine Keio University School Of Medicine
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Koretsune Yukihiro
Clinical Research Institute National Hospital Organization Osaka National Hospital
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Yamamoto Teppei
Division Of Cardiology And Regenerative Medicine Department Of Internal Medicine Nippon Medical School
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MITAMURA Hideo
Cardiology Division, Department of Medicine, Keio University School of Medicine
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Ohe Tohru
Cardiology, The Sakakibara Heart Institute of Okayama
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Inoue Hiroshi
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Yamazaki Tsutomu
Clinical Bioinformatics, University of Tokyo Graduate School of Medicine
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- PJ-065 An Epidemic of Systolic Heart Failure is being Realizing in an Urban Area in Japan Niigata-Sado Heart Failure Study(Heart failure, clinical-19 (M) PJ11,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Evaluation of Candidates of Biventricular Pacing Therapy in Idiopathic Dilated Cardiomyopathy
- Early and Long-Term Mortality of the Clinical Subtypes of Myocarditis
- Mutational Analysis of Cardiac Ryanodine Receptor Genes (RyR2) in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Arrhythmogenic Right Ventricular Cardiomyopathy(Arrhythmia, Basic 2 (A), The 69th Annual Scientific Meeting of the Ja
- PJ-201 A Compound Heterozygous Mutation in KCNQ1 Associated with Long QT Syndrome(Arrhythmia, basic(05)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-740 Hepatocyte Growth Factor (HGF), but not Vascular Endothelial Growth Factor (VEGF), Attenuated Ang II-induced EC Senescence by Inhibiting PIP3/rac1 Activity(PJ124,Peripheral Cirulation/Vascular Disease (Therapy) 4 (H),Poster Session (Japanese),The 7