<Original article>Effect of Valsartan, an Angiotensin-II-Receptor Antagonist, on Left Ventricular Hypertrophy in Type 2 Diabetic Patients

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概要

• 論文の詳細を見る

• Background: The aim of the present study was to examine the effects of an angiotensin-II-receptor antagonist, valsartan, on echocardiographically proven left ventricular hypertrophy in patients with Type 2 diabetes. Methods: Patients received a low dose of valsartan for 6 months. This low dose has no clinical effect on blood pressure. Echocardiographic data of 37 patients were analyzed. Results: After 6 months of valsartan therapy, the overall mean left ventricular mass index decreased slightly, from 109.0±26.1 to 108.1±22.0 g/m^2 (n=37). However a significant decrease was observed in the subgroup of patients with LVH (n=16), from 128.3±22.9 to 121.9±23.3 g/m^2 (P<0.05). There were no significant differences before and after treatment in body mass index, HbA_<1c>, or systolic or diastolic blood pressure. Conclusion: In Type 2 diabetic patients with left ventricular hypertrophy, treatment with valsartan for 6 months reduced the left ventricular mass index with no fall in systemic blood pressure.

• 新潟大学の論文

著者

• AIZAWA Yoshifusa

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Kato Kiminori

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• SUZUKI Katsunori

  Division of Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental S

• Kato Kiminori

  Division Of Endocrinology And Metabolism Department Of Homeostatic Regulation And Development Niigat

• SOUDA Satoshi

  Division of Endocrinology and Metabolism, Department of Homeostatic Regulation and Development, Niig

• Souda Satoshi

  Division Of Endocrinology And Metabolism Department Of Homeostatic Regulation And Development Niigat

• Suzuki Katsunori

  Division Of Endocrinology And Metabolism Niigata University Graduate School Of Medical And Dental Sc

• Aizawa Yoshifusa

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Suzuki Katsunori

  Division Of Endocrinology And Metabolism Graduate School Of Medical And Dental Sciences Niigata Univ

• Suzuki Katsunori

  新潟大学 医歯学総合研究科内分泌･代謝学分野

• AIZAWA Yoshifusa

  Division of Endocrinology and Metabolism, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences

• Kato Kiminori

  Division of Cardiology, Niigata Graduate School of Medical and Dental Sciences

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