Regulation of Endothelial Nitric Oxide Synthase and Endothelin-1 Expression by Fluvastatin in Human Vascular Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on endothelial vasoactive substances using human umbilical vein endothelial cells (HUVECs). Incubation of HUVECs with fluvastatin for 12 h increased endothelial nitric oxide synthase (eNOS) mRNA expression in a concentration-dependent manner (peak, 276 ± 38%, mean ± S.D., of the control, at 1.0 μM fluvastatin, P &0.01). In addition, fluvastatin increased eNOS protein production (245 ± 51% of the control level, P<0.05) as well as nitrite production (165 ± 35% of the control level, P<0.01). In contrast, incubation of HUVECs with 1.0 μM fluvastatin for 12 h significantly reduced the production of endothelin-1 (ET-1) and preproET-1 mRNA expression in HUVECs (28 ± 1% and 39 ± 1% of the control level, respectively, P <0.01). Our results suggest that fluvastatin might be involved in improvement of endothelial function and prevention of the progression of atherosclerosis.
- 社団法人 日本薬理学会の論文
- 2001-02-01
著者
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Yamamoto Tadashi
Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sc
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Aizawa Yoshifusa
First Department of Internal Medicine, Niigata University School of Medicine
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Ishibashi Takaharu
Department of Pharmacology, Kanazawa Medical University
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Nishio Matomo
Department of Pharmacology, Kanazawa Medical University
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Nishio Matomo
金沢医科大学 看護学部薬理学
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Nishio M
Department Of Pharmacology School Of Medicine Kanazawa Medical University
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Nishizawa M
Department Of Endocrinology Kanazawa Medical University
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Matsubara Taku
Shinrakuen Hospital
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Matsubara T
Division Of Cardiology Shinrakuen Hospital
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Matsubara Taku
新潟市民病院 循環器科
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Matsubara Taku
新潟大学 医歯学総合研究科循環器学分野
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Ishibashi Takaharu
金沢医科大学 看護学部薬理学
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Ishibashi Takaharu
Pharmacology School Of Nursing Kanazawa Medical University:department Of Pharmacology School Of Medi
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Ishii Takashi
Department Of Pharmacology Kanazawa Medical University
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Ishibashi Takaharu
旭川医科大学 薬理
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Yamamoto Tadashi
Department Of Cardiology Kouseikai Hospital
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Aizawa Y
First Department Of Internal Medicine Niigata University Graduate School Of Medical And Dental Scien
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Matsubara Taku
First Department of Internal Medicine
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OZAKI Kazuyuki
First Department of Internal Medicine, Institute of Nephrology, Niigata University School of Medicin
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Ohtaki Keita
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
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Ishibashi Takaharu
Department Of Pharmacology Asahikawa Medical College
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Yamamoto T
Division Of Oncology Department Of Cancer Biology Institute Of Medical Science University Of Tokyo
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Nishizawa Makoto
Division Of Endocrinology Department Of Internal Medicine
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Ozaki Kazuyuki
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
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Aizawa Yoshifusa
First Department Of Internal Medicine Niigata Universaity School Of Medicine
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Nishio Matomo
Department Of Endocrinology Kanazawa Medical University
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Yamamoto Tadashi
Departmanets of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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AIZAWA Yoshifusa
First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.
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