New Mehtods to Evaluate Endothelial Function : A Search for a Marker of Nitric Oxide (NO) In Vivo : Re-evaluation of NOx in Plasma and Red Blood Cells and a Trial to Detect Nitrosothiols
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概要
- 論文の詳細を見る
Although plasma NOx (NO2− and NO3−) has been used as an index of nitric oxide (NO) formation in vivo, many unreasonable results appeared even after active elimination of NOx contamination from laboratory ware. For example, plasma NOx concentrations did not increase during vasodilation mediated by the NO/cGMP pathway or after organ perfusion. A possible shift of NOx from plasma to erythrocytes (RBCs) as a cause of these phenomena has been excluded, leaving the destination of NOx (after leaving plasma) unknown. Kinetic analyses have revealed that steady state NOx concentrations in plasma and whole blood did not correlate with the NOx formation rate, but rather with the NOx elimination rate. Therefore, the supposition that the NO status is directly reflected by plasma NOx concentrations appears untenable. As nitrosothiols (R-SNOs), possible carriers of NO bioactivity, have been flagged as alternative indices of NO status in vivo, efforts have been made to detect these substances. When interference by ultrafiltration was eliminated, low molecular weight R-SNOs such as nitrosocystein and nitrosogluthathione were undetectable. However, a high-molecular weight R-SNO, nitrosoalbumin, was detected in human blood. Further research is required into the significance and practical use of nitrosoalbumin as a marker of NO in vivo.
- 社団法人 日本薬理学会の論文
- 2003-12-01
著者
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YOSHIDA Junko
Department of Pharmacology, Kanazawa Medical University
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Ishibashi Takaharu
Department of Pharmacology, Kanazawa Medical University
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Nishio Matomo
Department of Pharmacology, Kanazawa Medical University
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Nishio Matomo
金沢医科大学 看護学部薬理学
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Nishio M
Department Of Pharmacology School Of Medicine Kanazawa Medical University
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Nishizawa M
Department Of Endocrinology Kanazawa Medical University
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Ishibashi Takaharu
金沢医科大学 看護学部薬理学
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Ishibashi Takaharu
Pharmacology School Of Nursing Kanazawa Medical University:department Of Pharmacology School Of Medi
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Ishii Takashi
Department Of Pharmacology Kanazawa Medical University
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Ishibashi Takaharu
旭川医科大学 薬理
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Yoshida Junko
Department Of Pharmacology School Of Medicine Kanazawa Medical University
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Yoshida Junko
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
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Ishibashi Takaharu
Department Of Pharmacology Asahikawa Medical College
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Nishizawa Makoto
Division Of Endocrinology Department Of Internal Medicine
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Nishio Matomo
Department Of Endocrinology Kanazawa Medical University
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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