Significance of Asymmetric Dimethylarginine (ADMA) Concentrations During Coronary Circulation in Patients With Vasospastic Angina
スポンサーリンク
概要
- 論文の詳細を見る
The basal activity of nitric oxide (NO) is reduced in spastic arteries of patiots with vasospastic angina (VSA). Elevated concentrations of ADMA are associated with reduced NO production and impaired endothelium-dependent vasodilataion.The aim of this study was to elucidate the role of ADMA and its relationship to NO end-products (Nox ; nitrate+nitrite) during coronary circulation in patients with VSA.The plasma ADMA and Nox concentrations during coronary circulation were evaluated in 16 VSA and 16 control paticnts.Blood samples were obtained from the coronary sinus (V) and the ostium of the left coronary artry (A), and the (V-A) differences of ADMA and Nox were determined. The coronary sinus plasma ADMA concentration in patients with VSA was higher than that in the control. The coronary sinus-arterial (V-A) difference of NOx was negative in the VSA group and approximately zero in the control group (VSA group=-1.4μmol/L, control group=-0.1μmol/L, p=0.0005). Furthermore, in the VSA patients, there was a negative correlation between the (V-A) difference of NOx and the basal coronary artery tone at the site of spasm (r=-0.60,p=O.O15). A significant negative correlation between the (V-A) differences of NOx and ADMA was observed in patients with VSA (r=-0.52, p<0.05), but not in those of the control. Higher ADMA concentrations might cause the reduced formation of NO that underlies the pathophysiology of coronary vasospasm. (Cire J 2003 ; 67 : 305-311)
- 社団法人日本循環器学会の論文
- 2003-03-20
著者
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TSUCHIDA Keiichi
Department of Cardiology, Niigata City General Hospital
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Hori Tomoyuki
the First Department of Internal Medicine
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Matsubara Taku
the First Department of Internal Medicine
-
Ozaki Kazuyuki
the First Department of Internal Medicine
-
Tsuchida Keiichi
the First Department of Internal Medicine
-
Aizawa Yoshifusa
the First Department of Internal Medicine
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Ishibashi Takaharu
Department of Pharmacology, Kanazawa Medical University
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Nishio Matomo
Department of Pharmacology, Kanazawa Medical University
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Nishio Matomo
金沢医科大学 看護学部薬理学
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Nishio M
Department Of Pharmacology School Of Medicine Kanazawa Medical University
-
Nishizawa M
Department Of Endocrinology Kanazawa Medical University
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Matsubara Taku
Shinrakuen Hospital
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Matsubara T
Division Of Cardiology Shinrakuen Hospital
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Matsubara Taku
新潟大学 医歯学総合研究科循環器学分野
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Ishibashi Takaharu
金沢医科大学 看護学部薬理学
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Ishibashi Takaharu
Pharmacology School Of Nursing Kanazawa Medical University:department Of Pharmacology School Of Medi
-
Ishii Takashi
Department Of Pharmacology Kanazawa Medical University
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Ishibashi Takaharu
旭川医科大学 薬理
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Hori Tomoyuki
新潟大学 医歯学総合研究科循環器学分野
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Hori Tomoyuki
Divisions Of Cardiology
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Yamaura Masayuki
Department Of Cardiology Niigata City General Hospital
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Murakawa Yuji
The Second Department Of Internal Medicine. Faculty Of Medicine University Of Tokyo
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Tsuchida Keiichi
Department Of Cardiology Niigata City General Hospital
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Matsubara Taku
First Department of Internal Medicine
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YAMAZOE Masaru
Division of General Medicine, Niigata City General Hospital
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Ohtaki Keita
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
-
Mezaki Toru
Divisions Of Cardiology
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Matsubara T
First Department Of Internal Medicine Institute Of Nephrology Niigata University School Of Medicine
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Nakamura Yuichi
Nagaoka Chuo General Hospital
-
Yamazoe Masaru
Niigata City General Hospital
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Yamazoe Masaru
First Department Of Internal Medicine
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Mezaki Tohru
The First Departiment of Internal Medicine,Niigata University School of Medicine
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Tanaka Takayuki
The First Departiment of Internal Medicine,Niigata University School of Medicine
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Nasuno Akimitsu
The First Departiment of Internal Medicine,Niigata University School of Medicine
-
Kubota Kaname
The First Departiment of Internal Medicine,Niigata University School of Medicine
-
Nakamura Yuichi
The First Departiment of Internal Medicine,Niigata University School of Medicine
-
Nasuno Akimitsu
Divisions Of Cardiology
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Ishibashi Takaharu
Department Of Pharmacology Asahikawa Medical College
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Kubota Kaname
The First Departiment Of Internal Medicine Niigata University School Of Medicine
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Yamazoe Masaru
First Department Of Medicine Niigata University
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Nishizawa Makoto
Division Of Endocrinology Department Of Internal Medicine
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Ozaki Kazuyuki
Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences
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Makiyama Yashiro
Niigata City General Hospital
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Nishio Matomo
Department Of Endocrinology Kanazawa Medical University
-
Tanaka Takayuki
Divisions Of Cardiology
-
Murakami Yuji
The Second Department Of Internal Medicine. Faculty Of Medicine University Of Tokyo
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Aizawa Yoshifusa
The First Department Of Internal Madicine Niigata University School Of Medicine
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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