Effect of carvedilol on venous return: A mechanism of reduction in blood pressure.
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概要
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We studied the effect of carvedilol, a β-blocker with a potent α-blocking activity, on venous return in anesthetized dogs. Though 3μg/kg of carvedilol caused a slight increase in blood pressure and total peripheral resistance, these changes disappeared by further doses of the agent. On the other hand, each dose of carvedilol (3-100 μg/kg) decreased venous return significantly and dose-dependently. These results indicate that the hypotensive effect of carvedilol mainly depends on the decrease in venous return rather than arterial vasodilation.
- 公益社団法人 日本薬理学会の論文
著者
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HAMAGUCHI Masami
Department of Pharmacology, Niigata University School of Medicine
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KATSUMATA Naoki
Department of Pharmacology, Niigata University School of Medicine
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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Hamaguchi Masami
Department Of Pharmacology Niigata University School Of Medicine
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Katsumata Naoki
Department Of Pharmacology Niigata University School Of Medicine
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Okuhira Masayasu
Department Of Pharmacology Niigata University School Of Medicine
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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