Cardiotonic and coronary vasodilatatory effects of amrinone in the canine heart-lung preparation with a support dog as compared with those of dobutamine.
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概要
- 論文の詳細を見る
Analysis of the relative magnitude of the positive inotropic and chronotropic effects and the coronary vasodilating effects of amrinone conducted in the canine heart-lung preparation with a support dog in comparison with those of dobutamine demonstrated that amrinone was a preferential coronary vasodilator rather than a selective positive inotropic agent. An in vitro experiment in the canine papillary muscle suggested the initiation of the slow response action potential as a mechanism of the positive inotropic effect of amrinone.
- 公益社団法人 日本薬理学会の論文
著者
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Imai Hirohisa
Department Of Epidemiology National Institute Of Public Health
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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NAKAHARA Hajime
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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MATSUI Kazuki
Department of Pharmacology, Niigata University School of Medicine
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IMAI Hirohisa
Department of Pharmacology, Niigata University School of Medicine
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TAKEDA Keisuke
Research Laboratories, Chugai Pharmaceutical Co., Ltd
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