ANTIARRHYTHMIC EFFECT OF OXPRENOLOL ON HALOTHANE-EPINEPHRINE AND CORONARY LIGATION INDUCED VENTRICULAR ARRHYTHMIAS IN BEAGLE DOGS
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概要
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Antiarrhythmic effects of oxprenolol, a β-blocker, were studied quantitatively on arrhythmias produced by epinephrine during halothane anesthesia and by two-stage coronary ligation, and were compared to those of other β-blockers, propranolol and Kö 1400, which have been already reported. Though oxprenolol has potent β-blocking activity, the antiarrhythmic effect on halothane-epinephrine arrhythmia was significantly weaker than those of propranolol and Kö 1400. The effective dose of oxprenolol was 60±18 μg/kg (means±S.E., N=6), which is in the range of the so-called β-adrenergic blocking dose. The weaker antiarrhythmic effect of oxprenolol as compared to propranolol and Kö 1400 is probably due to the intrinsic positive chronotropic effect, which is most clearly observed in oxprenolol as compared to the other two drugs. As for two-stage coronary ligation arrhythmia, oxprenolol suppressed only that observed 48 hours after coronary ligation using higher doses (5 to 10 mg/kg). Other β-blockers also showed similar effects. Because of the high doses necessary for the antiarrhythmic effects on the coronary ligation arrhythmia, the mechanism for suppressing the arrhythmia is probably due to the local anesthetic action of the β-blockers.
- 社団法人 日本薬理学会の論文
著者
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Matsuda Hiroto
Department Of Gastroenterology Ishikawa Prefectural Central Hospital
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MATSUBARA Issei
Department of Pharmacology, Niigata University School of Medicine
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Tsukada Tokumasa
Department Of Pharmacology Niigata University School Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Niigata University School Of Medicine
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HASHIMOTO Keitaro
Department of Pharmacology, Niigata University, School of Medicine
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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MATSUBARA Issei
Department of Pharmacology, Niigata University, School of Medicine
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MATSUBARA Issei
Department of Pharmacology Niigata University School of Medicine Niigata
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MATSUDA Hiroto
Department of Pharmacology, Niigata University, School of Medicine
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TSUKADA Tokumasa
Department of Pharmacology, Niigata University, School of Medicine
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