EFFECT OF NITROGLYCERIN ON Ca EFFLUX IN THE CORONARY ARTERY
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概要
- 論文の詳細を見る
Effects of nitroglycerin on the <SUP>45</SUP>Ca efflux were studied on the isolated coronary artery preparation of the dog. After loading with <SUP>45</SUP>Ca for 3 hours and rinsing with cold physiological salt solution (PSS), the preparation was transferred to a series of vials containing oxygenated PSS at 10 min intervals. After 100 min, Ca efflux was induced from within the cell by metabolic inhibition with dinitrophenol plus monoiodoacetate following the method of Van Breemen et al. (1975). Nitroglycerin did not produce any effect on the Ca efflux. Although not complete, lanthanum (1 mM) produced an inhibition of the Ca efflux, which was not reversed by nitroglycerin. It is concluded that our previous findings of relaxation of the lanthanum contracture of the coronary artery by nitroglycerin was not brought about by an increase in Ca efflux from the coronary artery.
- 社団法人 日本薬理学会の論文
著者
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Nakazawa Mikio
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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IMAI Shoichi
Department of Pharmacology, Niigata University School of Medicine
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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