Hypotensive and Vascular Effects of Labetalol in the Normotensive Rat and Dog
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概要
- 論文の詳細を見る
A new antihypertensive agent, labetalol, has potent hypotensive effects in the anesthetized rat and dog when given intravenously and also in the unanesthetized beagle when given orally. Labetalol slightly increased renal blood flow of the anesthetized dog while decreasing blood pressure. Labetalol slightly increased blood flow of canine femoral artery under constant pressure perfusion. However as compared with hydralazine, labetalol seems to have no marked vasodilatatory effect which accounts for its hypotensive effect.Pharmacologically, labetalol possessed both α- and β-blocking activities, though weaker than phentolamine and propranolol respectively. Another specific action of labetalol was that it has stronger β-blocking action on β1 receptor (heart rate response) than on β2 receptor (blood pressure response). Like several other β-blockers, Labetalol seems to block neuronal uptake of noradrenaline.
- International Heart Journal刊行会の論文
著者
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Iizuka Hiromi
Department Of Pharmacology Preclinical Research Laboratories Central Institute For Experimental Anim
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Matsuda Hiroto
Department Of Gastroenterology Ishikawa Prefectural Central Hospital
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Tsukada Tokumasa
Department Of Pharmacology Niigata University School Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Toyozo
Department Of Cardiology And Internal Medicine
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Hashimoto Keitaro
Department Of Pharmacology Niigata University School Of Medicine
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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IIZUKA Hiromi
Department of Pharmacology, Niigata University School of Medicine
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