EFFECTS OF PROSTAGLANDINS ON LATE CORONARY LIGATION ARRHYTHMIAS IN THE DOG
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概要
- 論文の詳細を見る
Effects of an intravenous injection of indomethacin, prostaglandins (PGs) E<SUB>1</SUB>, E<SUB>2</SUB> and F<SUB>2α</SUB> and prostacyclin were examined by the use of a model of two-stage coronary ligation arrhythmias in conscious dogs. Indomethacin had no effect on the arrhythmias occurring 48 hr after coronary ligation. PGs and prostacyclin were injected after the injection of indomethacin. PGs did not show any significant antiarrhythmic effects on the arrhythmias occurring 48 hr after coronary ligation, while prostacyclin showed a transient arrhythmogenic effect. From the foregoing results, both endogenous and exogenous PGs do not seem to play a significant role in the genesis of late coronary ligation arrhythmias in the dog.
- 社団法人 日本薬理学会の論文
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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IMAI Shoichi
Department of Pharmacology, Niigata University School of Medicine
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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SHIBUYA TOSHIYUKI
Department of Phamacology, Niigata University School of Medicine
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Shibuya Toshiyuki
Department Of Phamacology Niigata University School Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Niigata University School Of Medicine
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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SHIBUYA Toshiyuki
Department of Pharmacology, Niigata University School of Medicine
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