DEVELOPMENT OF CORONARY COLLATERAL CIRCULATION IN MINIATURE SWINE AND EFFECTS OF SEVERAL DRUGS
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概要
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To determine whether or not the development of collateral channels can be accelerated by administration of vasodilators and whether the opening up of functional collateral channels is associated with an improved survival rate, a gradual occlusion of the major branches of the left coronary artery was produced in miniature swine with an Ameroid constrictor. Oral administration of drugs (twice a day) was started seven days before operation and was continued throughout the experimental period of 2 months. While the survival rate of the untreated animals was 6/15 (40%), survival rates of animals treated with adenosine potentiators, dipyridamole and dilazep were 4/7 (57.1%) and 5/7 (71.4%), respectively. However, a significant improvement of the survival rate was attained by KI 2119, survival rate was 6/7 (85.7%). Coronary angiography of the survived control animals revealed numerous, fine, collateral communications between the left and right coronary arteries. Treatment with dipyridamole and dilazep resulted in formation of a dense network of thick collaterals. To quantitate the degree of formation of the collateral channels, the anatomic anastomotic indices (AAIs) were calculated using histological specimens of the anterior free wall of the left ventricle. According to Menick et al. (16), AAI is a good measure of the functional capacity of the collateral vessels. AAIs of the animals treated with dipyridamole and dilazep were 2416.6±454.0 and 1864.7±248.3 as compared with 704.3±407.9 of the untreated animals. AAIs of the KI 2119-treated animals did not differ from those of the control animals. A linear correlation was observed between the survival rate and AAIs (r=0.74, p<0.05), indicating a close relationship between the survival rate and the development of functional collateral channels.
- 社団法人 日本薬理学会の論文
著者
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Sakurai Hiroshi
Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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Katano Yumi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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MATSUBARA Issei
Department of Pharmacology, Niigata University School of Medicine
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Nakagawa Yoshito
Department Of Pharmacology Niigata University School Of Medicine
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Takeda Keisuke
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Otorii Takeshi
Department Of Pharmacology Niigata University Schcol Of Medicine
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Hashimoto Toyozo
Department Of Cardiology And Internal Medicine
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NABATA Hiroyuki
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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OGASAWARA Sadanori
Department of Pharmacology, Niigata University School of Medicine
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YOKOYAMA Hiromi
Department of Pharmacology, Niigata University School of Medicine
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OTORII Takeshi
Department of Phamacology, Niigata University School of Medicine
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MATSUBARA Issei
Department of Pharmacology Niigata University School of Medicine Niigata
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