A Comparative Study of Characteristics of Current-Type and Conventional-Type Cationic Bactericides
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概要
- 論文の詳細を見る
We have synthesized new polycationic bactericides, poly[oxyethylene(dimethyliminio)trimethylene(dimethyliminio)ethylene dichloride](OXD)and poly(hexamethyleneguanidine phosphate)(HEP), in order to develop more active but less skin-irritative bactericides. The effects of these bactericides on Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Klebsiella pneumoniae, methicillin resistant Staphylococcus aureus(MRSA)and the degree of their irritations on skin were compared with those of a widely used low molecular-weight cationic bactericide, benzalkonium chloride(BAC), and a polycationic bactericide, poly[2-hydroxyethylene(dimethyliminio)methylene chloride](2HYC). The minimum bactericidal concentration(MBC)of OXD for 10 min contact incubation was 16μg/ml against P.aeruginosa, E.coli, S.marcescens and K.pneumoniae, and >1000μg/ml against MRSA. The MBC of HEP for 10 min contact incubation was 16μg/ml against P.aeruginosa, 32μg/ml against E.coli and K.pneumoniae, and 64μg/ml against S.marcescens and MRSA. Itch, edema, erythema, heat, injury, desquamation and keratinization caused by skin irritation were examined in 21 subjects by patch tests. Only one subject treated with OXD experienced edema, and one subject with HEP experienced keratinization. However, BAC caused itch in 3 subjects, edema in 1, erythema in 10 and desquamation in 2, indicating that the incidence of skin irritation of BAC was higher than that of OXD or HEP. OXD and HEP had sterilization ability similar to BAC, however, they were less skin-irritative than BAC. This indicates that OXD and HEP can be used as safe bactericides.
- 2001-09-01
著者
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MAKINO Mitsuko
Department of Chemistry, College of Humanities and Sciences, Nihon University
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OHTA SHIN
Department of Pharmacy, Shinshu University Hospital
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NAGAI KATSUHIRO
Department of Pharmacy, Shinshu University Hospital
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ZENDA HIROSHI
Department of Pharmacy, Shinshu University Hospital
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YAMATO Susumu
Department of Analytical Chemistry, Niigata College of Pharmacy
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TACHIKAWA Eiichi
Department of Pharmacology, School of Medicine, Iwate Medical University
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SHIRAISHI Tadashi
Department of Communications, Tokai University
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Ohta S
Department Of Functional Molecular Chemistry Kyoto Pharmaceutical University
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Ohta Shin
Pharmaceutical Health Care And Sciences Tokyo Univ. Of Pharmacy And Life Sci.
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Ohta Shin
Department Of Hospital Pharmacy Shinshu University School Of Medicine
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Zenda Hiroshi
Department Of Pharmacokinetics Hoshi University
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大和 進
Pharmaceutical And Analytical Chemistry Niigata Univ. Of Pharmacy And Applied Life Sciences
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Makino M
College Of Pharmacy Nihon University
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Makino Mitsuko
Department Of Chemistry College Of Humanities And Sciences Nihon University
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NAKAGAWA YOSHITO
Department of Pharmacy, Yamagata University Hospital
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Miyamoto H
Department Of Research And Development Nicca Chemical Co. Ltd.
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Tachikawa E
Department Of Pharmacology School Of Medicine Iwate Medical University
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Tachikawa Eiichi
Department Of Pharmacology Faculty Of Pharmacy Iwate Medical University
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MISAWA Yuka
Department of Pharmacy, Shinshu University Hospital
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MIYAMOTO Hidekazu
Department of Research and Development, Nicca Chemical Co., Ltd.
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MAKINO Masahiro
Department of Research and Development, Nicca Chemical Co., Ltd.
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Misawa Y
Department Of Pharmacy Shinshu University Hospital
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Misawa Yuka
Department Of Pediatrics Shinshu University School Of Medicine
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Makino Masahiro
Department Of Research And Development Nicca Chemical Co. Ltd.
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Nakayama K
Department Of Pharmacy Shinshu University Hospital
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Nakagawa Yoshito
Department Of Pharmacology Niigata University School Of Medicine
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Matsumoto Hideki
Department Of Experimental Radiology And Health Physics Fukui Medical University
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Shiraishi Tadashi
Department Of Pharmacy Yamagata University Hospital
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Shiraishi Tadashi
Department Of Communication Engineering Tokai University
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Tachikawa Eiichi
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Sciences
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Miyamoto Hidekazu
Department of Biopharmaceutics, School of Pharmaceutical Sciences, Osaka University
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Yamato Susumu
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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Ohta Shin
Department of Functional Molecular Chemistry, Kyoto Pharmaceutical University
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NAGAI KATSUHIRO
Department of Pharmacy
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Makino Masahiro
Department of Neurology, Japanese Red Cross Kyoto Daini Hospital, Japan
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Shiraishi Tadashi
Department of Chemistry, Faculty of Science, Chiba University
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