In vitro pharmacological activities of the extracts from red ant Formica aquilonia as potential therapeutic agents

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概要

• 論文の詳細を見る

• The extracts of Chinese red ant Formica aquilonia were screened for cytotoxicity, antioxidation and anti-inflammatory properties, prolyl oligopeptidase (POP) inhibition, and the effect on the catecholamine secretion. Dried ants were successively extracted with hexane, ethyl acetate, aqueous acetone and distilled water. Both the hexane and ethyl acetate extracts exhibited a high level of POP inhibitory activity; ethyl acetate extract was also significantly cytotoxic against the rat liver cancer cells. In the assay with anti-inflammatory assay, the residue of hexane extract suppressed weakly COX-2 activity. Inhibition of the acetylcholine-dependent catecholamine secretion from the bovine adrenal chromaffin cells was most pronounced with the ethyl acetate extract. The aqueous acetone extract exhibited antioxidant activity in a diphenylpierylhydrazyl assay. These results indicate that F. aquilonia contains promising therapeutic agents.

• 和漢医薬学会の論文

著者

• Sato Yoshinori

  Department of Environmental Infectious Diseases, Graduate School of Medical Sciences, Kitasato Unive

• Suzuki Koichi

  Faculty of Agriculture, Iwate University

• YANG Ping

  Faculty of Agriculture, Iwate University

• Yang Ping

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Yamamoto Kei-ichiro

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Suzuki Koichi

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Tachikawa Eiichi

  Department Of Pharmacology Faculty Of Pharmacy Iwate Medical University

• Shinada Tetsuro

  Graduate School Of Science Osaka City University

• Yamamoto Kei‐ichiro

  Iwate Univ. Morioka Jpn

• PIAO Chunhong

  Department of Agro-Bioscience, Faculty of Agriculture, Iwate University

• HU Yaohui

  College of Food Engineering, Jinlin Agricultural University

• Hu Yaohui

  College Of Food Engineering Jinlin Agricultural University

• Piao Chunhong

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University:college Of Food Engineering Ji

• Sato Yoshinori

  Faculty Of Agriculture Iwate University

• Yang Ping

  Faculty Of Agriculture Iwate University

• Suzuki Koichi

  Faculty Of Agriculture Iwate University

• Sato Yoshinori

  Department Of Bioresource Science Ibaraki University College Of Agriculture

• Tachikawa Eiichi

  Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Sciences

• SATO Yoshinori

  Department of Bioclimatology and Medicine. Research Institute of Bioregulation. Kyushu University

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