DEVELOPMENT AND EVALUATION OF A NEW PERORAL TEST AGENT GA-TEST FOR ASSESSMENT OF GASTRIC ACIDITY
スポンサーリンク
概要
- 論文の詳細を見る
A new peroral test capsule, GA-Test, containing riboflavin (5mg) granules coated with polyvinylacetal diethylaminoacetate (AEA【○!R】) for assessing gastric acidity without intubation was developed and evaluated for usefulness. GA-Test is based on the tracing in the urine of riboflavin, which is released in the stomach only in the presence of acidic fluid and is absorbed. Due to the film coating, riboflavin released very quickly at a pH of less than 5,and not at all at a pH of greater than 6. GA-Test gave a significant correlation, quantitatively, with peroral Gastrotest【○!R】 in assessing acidity, a non-intubation method which had been marketed in Japan prior to 1980. GA-Test results allowed division of the subjects into two groups i.e., subjects having low (hypo-or anacidity) gastric acidity and those having high (normal or hyperacidity) gastric acidity, GA-Test results agreed well with results of intubation (around 91.4% ; 32 out of 35 cases) and were easily reproduced during the evaluation.
- 社団法人日本薬学会の論文
著者
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SUZUKI Koichi
Department of Pediatrics, Hirosaki University School of Medicine
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Kaniwa Nahoko
National Institute Of Health Sciences
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Kaniwa Nahoko
Division Of Drugs National Institute Of Hygienic Sciences
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EJIMA AKIRA
National Institute of Hygienic Sciences
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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Ogata Hiroyasu
国立医薬品食品衛生研究所
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Ogata Hiroyasu
Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.
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Aoyagi Nobuo
National Institute Of Health Sciences
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Aoyagi Nobuo
国立医薬品食品衛生研究所
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Ejima Akira
Drugs Division National Institute Of Hygienic Sciences
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OGATA HIROYASU
Division of Drugs, National Institute of Hygienic Sciences
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AOYAGI NOBUO
Division of Drugs, National Institute of Hygienic Sciences
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EJIMA AKIRA
Division of Drugs, National Institute of Hygienic Sciences
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ISHIOKA TADAO
Department of Internal Medicine and Geriatrics, Nakano Sohgoh General Hospital
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MORISHITA MASATAKA
Pharmaceutical Research Laboratory, Toyo Jyozo Co., Ltd.
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OHTA KATSUTOSHI
Pharmaceutical Research Laboratory, Toyo Jyozo Co., Ltd.
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TAKAGISHI YASUSHI
Production Division, Shionogi & Company Ltd.
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DOI YOSHIO
Production Division, Shionogi & Company Ltd.
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OGURA TOSHIHIRO
Production Division, Shionogi & Company Ltd.
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Takagishi Yasushi
Production Division Shionogi & Company Ltd.
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Ishioka Tadao
Department Of Internal Medicine And Geriatrics Nakano Sohgoh General Hospital
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Ohta Katsutoshi
Pharmaceutical Research Laboratory Toyo Jyozo Co. Ltd.
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OGATA Hiroyasu
明治薬科大学大学院臨床薬学薬剤学
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Aoyagi N
National Institute Of Health Sciences
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Aoyagi Nobuo
Division Of Drugs National Institute Of Hygienic Sciences
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Ogata Hiroyasu
Department Of Biopharmaceutics Meiji Pharmaceutical University
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Ogura Toshihiro
Production Division Shionogi & Company Ltd.
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Ogura Toshihiro
Production & Engineering Division Heraeus Electro-nite Japan Ltd.
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Morishita Masataka
Pharmaceutical Research Laboratory Toyo Jyozo Co. Ltd.
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Suzuki Koichi
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
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Doi Yoshio
Production Division Shionogi & Company Ltd.
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Suzuki Koichi
Department Of Gastroenterology Ohkura National Hospital
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