DEVELOPMENT AND EVALUATION OF A NEW PERORAL TEST AGENT GA-TEST FOR ASSESSMENT OF GASTRIC ACIDITY

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概要

• 論文の詳細を見る

• A new peroral test capsule, GA-Test, containing riboflavin (5mg) granules coated with polyvinylacetal diethylaminoacetate (AEA【○!R】) for assessing gastric acidity without intubation was developed and evaluated for usefulness. GA-Test is based on the tracing in the urine of riboflavin, which is released in the stomach only in the presence of acidic fluid and is absorbed. Due to the film coating, riboflavin released very quickly at a pH of less than 5,and not at all at a pH of greater than 6. GA-Test gave a significant correlation, quantitatively, with peroral Gastrotest【○!R】 in assessing acidity, a non-intubation method which had been marketed in Japan prior to 1980. GA-Test results allowed division of the subjects into two groups i.e., subjects having low (hypo-or anacidity) gastric acidity and those having high (normal or hyperacidity) gastric acidity, GA-Test results agreed well with results of intubation (around 91.4% ; 32 out of 35 cases) and were easily reproduced during the evaluation.

• 社団法人日本薬学会の論文

著者

• SUZUKI Koichi

  Department of Pediatrics, Hirosaki University School of Medicine

• Kaniwa Nahoko

  National Institute Of Health Sciences

• Kaniwa Nahoko

  Division Of Drugs National Institute Of Hygienic Sciences

• EJIMA AKIRA

  National Institute of Hygienic Sciences

• Ogata Hiroyasu

  Deparment Of Biopharmaceutice Meiji Pharmaceutical University

• Ogata Hiroyasu

  国立医薬品食品衛生研究所

• Ogata Hiroyasu

  Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.

• Aoyagi Nobuo

  National Institute Of Health Sciences

• Aoyagi Nobuo

  国立医薬品食品衛生研究所

• Ejima Akira

  Drugs Division National Institute Of Hygienic Sciences

• OGATA HIROYASU

  Division of Drugs, National Institute of Hygienic Sciences

• AOYAGI NOBUO

  Division of Drugs, National Institute of Hygienic Sciences

• EJIMA AKIRA

  Division of Drugs, National Institute of Hygienic Sciences

• ISHIOKA TADAO

  Department of Internal Medicine and Geriatrics, Nakano Sohgoh General Hospital

• MORISHITA MASATAKA

  Pharmaceutical Research Laboratory, Toyo Jyozo Co., Ltd.

• OHTA KATSUTOSHI

  Pharmaceutical Research Laboratory, Toyo Jyozo Co., Ltd.

• TAKAGISHI YASUSHI

  Production Division, Shionogi & Company Ltd.

• DOI YOSHIO

  Production Division, Shionogi & Company Ltd.

• OGURA TOSHIHIRO

  Production Division, Shionogi & Company Ltd.

• Takagishi Yasushi

  Production Division Shionogi & Company Ltd.

• Ishioka Tadao

  Department Of Internal Medicine And Geriatrics Nakano Sohgoh General Hospital

• Ohta Katsutoshi

  Pharmaceutical Research Laboratory Toyo Jyozo Co. Ltd.

• OGATA Hiroyasu

  明治薬科大学大学院臨床薬学薬剤学

• Aoyagi N

  National Institute Of Health Sciences

• Aoyagi Nobuo

  Division Of Drugs National Institute Of Hygienic Sciences

• Ogata Hiroyasu

  Department Of Biopharmaceutics Meiji Pharmaceutical University

• Ogura Toshihiro

  Production Division Shionogi & Company Ltd.

• Ogura Toshihiro

  Production & Engineering Division Heraeus Electro-nite Japan Ltd.

• Morishita Masataka

  Pharmaceutical Research Laboratory Toyo Jyozo Co. Ltd.

• Suzuki Koichi

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Doi Yoshio

  Production Division Shionogi & Company Ltd.

• Suzuki Koichi

  Department Of Gastroenterology Ohkura National Hospital

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