Gastric Emptying Rates of Drug Preparations. I. Effects of Size of Dosage Forms, Food and Species on Gastric Emptying Rates
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概要
- 論文の詳細を見る
The gastric emptying rates of oral dosage forms of different sizes were studied in humans and beagle dogs measuring of marker drugs such as acetaminophen, aspirin and pyridoxal phosphate in plasma or urine. The marker drugs, except acetaminophen, were contained in enteric-coated granules or tablets which did not dissolve in the stomach but dissolved rapidly in the upper intestine. The gastric emptying rate of a dosage form of smaller size was faster than that of a larger size. The gastric emptying rates of dasage forms with different sizes did not correlate with each other inter-individually. The gastric emptying rates of dosage forms of any size were delayed when drugs were administered after taking a meal. The gastric emptying rates of dosage forms were extremely prolonged in beagle dogs after drug administration postprandially, and this restricted the use of beagle dogs as an animal model in bioavailability tests.
- 社団法人日本薬学会の論文
著者
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Kaniwa Nahoko
National Institute Of Health Sciences
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EJIMA AKIRA
National Institute of Hygienic Sciences
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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Ogata Hiroyasu
国立医薬品食品衛生研究所
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Ogata Hiroyasu
Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.
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Aoyagi Nobuo
National Institute Of Health Sciences
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Aoyagi Nobuo
国立医薬品食品衛生研究所
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Ejima Akira
Drugs Division National Institute Of Hygienic Sciences
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KANIWA Nahoko
Drugs Division, National Institute of Hygienic Sciences
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AOYAGI Nobuo
Drugs Division, National Institute of Hygienic Sciences
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OGATA Hiroyasu
Drugs Division, National Institute of Hygienic Sciences
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OGATA Hiroyasu
明治薬科大学大学院臨床薬学薬剤学
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Aoyagi N
National Institute Of Health Sciences
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Ogata Hiroyasu
Department Of Biopharmaceutics Meiji Pharmaceutical University
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Ogata H
Meiji Pharmaceutical Univ. Tokyo Jpn
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