Isolation of a Major Metabolite (i-OHAP) of Aprindine and Its Identification as N-[3-(N, N-Diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol
スポンサーリンク
概要
- 論文の詳細を見る
i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-[3-(N, N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol, based on ^1H-NMR, the H-H correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its structure was also confirmed by comparison with the synthesized compound. The hydroxy group of i-OHAP was located at the 5-position of the indan ring. AP is a prochiral compound, and the metabolism of AP to i-OHAP was stereoselective. The ratio of (+)/(-)-i-OHAP in rat feces and in human urine was about 5 and 15,respectively.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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Ogata Hiroyasu
Department of Biopharmaceutics, Meiji Pharmaceutical University
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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TAKATORI KAZUHIKO
Department of Medicinal Chemistry, Meiji Pharmaceutical University
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Ogata Hiroyasu
Department Of Biopharmaceutics
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Shimizu Mikiko
Department Of Clinical Pharmacology Hirosaki University School Of Medicine
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Shimizu Mikiko
Department Of Biopharmaceutics
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Shimizu Mikiko
Department Of Biological Science And Technology Faculty Of Industrial Science And Technology Science
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KAJIWARA Masahiko
Department of Medicinal Chemistry, Meiji College of Pharmacy
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Kajiwara Masahiko
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Takatori Kazuhiko
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Kajiwara Masahiro
Department Of Legal Medicine Kyorin University School Of Medicine
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