Screening System for Urease Inhibitors Using ^<13>C-NMR
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概要
- 論文の詳細を見る
Urease inhibitors are candidate drugs to treat infection with the human pathogen, Helicobacter pylori, which produces a potent urease [urea amidohydrolase; EC 3.5.1.5]. We developed a screening system based on ^<13>C-NMR measurement of the time course of decrease in the signal of ^<13>C-urea in the presence of urease. The effect on urease activity of known inhibitors, hydroxamic acids, L-ascorbic acid, 2,2'-dipyridyl disulfide and ninhydrin, was speedily and conveniently measured by this method.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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Tahara K
Second Department Of Internal Medicine Kochi Medical School
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Takatori Kazuhiro
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Iida Katsumi
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Iida Katsumi
Department Of Medical Chemistry Meiji College Of Pharmacy
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Takatori Kazuhiko
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Kajiwara Masahiro
Department Of Legal Medicine Kyorin University School Of Medicine
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CHIYODA Takeshi
Department of Medicinal Chemistry, Meiji College of Pharmacy
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Chiyoda Takeshi
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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