Studies on ^<13>C-Phenacetin Metabolism. II. A Combination of Breath Test and Urine Test of in Vivo Metabolites in the Diagnosis of Liver Disease

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We determined the optimum ^<13C>-labeling position in phenacetin for use in a breath test to diagnose liver disease based on infrared spectroscopy detection of ^<13>CO_2 in exhaled air. ([1-^<13>C]Ethoxy)phenacetin gave the best result. This compound was also employed in a urine test using ^<13>C-NMR spectroscopy. In the urine test, healthy subjects gave a higher signal of phenacetin than of its metabolite, phenetidine, whereas in patients with liver disease the situation was the reverse. The combination of the breath and urine tests may be a valuable new tool for the diagnosis of liver disease.
公益社団法人日本薬学会の論文
1996-06-15