Studies on the Biosynthesis of Corrinoids and Porphyrinoids.II. : The Origin of Nitrogen of Vitamin B_<12>
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概要
- 論文の詳細を見る
To clarify the origin of nitrogen of vitamin B_<12>, ^<15>N-labeled aminolevulinic acid (ALA) was prepared and administered to Propionibacterium shermanii. Vitamin B_<12> thus isolated showed four signals in the nitrogen-15 nuclear magnetic resonance (^<15>N-NMR) spectrum. The nitrogen of [5-^<15>N]riboflavine was incorporated into the benzimidazole part of vitamin B_<12>. Hydroxycobalamin was transformed into cyanocobalamin by treatment with [^<15>N]potassium cyanide, and the ^<15>N-NMR spwctrum was measured. The results of these experiments revealed the origin of the nitrogen atoms of vitamin B_<12>, and allowed the ^<15>N-NMR signals to be assigned.
- 社団法人日本薬学会の論文
- 1990-04-25
著者
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車谷 勝行
Department of Medicinal Chemistry, Meiji College of Pharmacy
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梶原 正宏
Department of Medicinal Chemistry, Meiji College of Pharmacy
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車谷 勝行
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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梶原 正宏
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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岡崎 健男
Department of Medicinal Chemistry, Meiji College of Pharmacy
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岡崎 健男
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Okazaki Takeo
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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