Biosynthesis of Erythromycin : Origin of the Methyl Protons
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概要
- 論文の詳細を見る
^<13>C-Nuclear magnetic resonance (^<13>C-NMR) spectroscopy has been used to locate deuterium atoms incorporated biosynthetically into erythromycin from [3-^<13>CD_3]- and [3-^<13>C]sodium propionate and L-[^<13>CD_3]- and L-[^<13>C]methionine in Saccharopolyspora erythraea JCM 4748. The α-shifts of deuterated methyl groups were clearly observed in broad-band deuterium and proton-decoupled ^<13>C-NMR spectra. The seven propionate-derived methyl groups and the four methionine-derived methyl groups were shown to undergo no exchange of methyl protons during the biosynthesis of erythromycin.
- 社団法人日本薬学会の論文
- 1994-07-15
著者
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梶原 正宏
Department of Medicinal Chemistry, Meiji College of Pharmacy
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梶原 正宏
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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上垣 隆一
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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飯田 克巳
明治薬科大学薬学部薬品化学教室
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飯田 克巳
Department of Medicinal Chemistry, Meiji College of Pharmacy
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和田 陽子
Department of Medicinal Chemistry, Meiji College of Pharmacy
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和田 陽子
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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