A New Biosynthetic Pathway of Prophyrins from Isopropanol
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概要
- 論文の詳細を見る
A new biosynthetic pathway, which can produce both vitamin B_<12> and large amounts of porphyrins from isopropanol, was identified in Arthrobacter hyalinus using carbon-13 stable isotope tracer techniques and carbon-13 nuclear magnetic resonance (^<13>C-NMR) spectroscopy. Studies on the incorporation of [2-^<13>C]isopropanol, [l- or 2-^<13>C]sodium acetate, L-[l-^<13>C]glutamate, and [1-, 2-, 3-, 4-, 5-^<13>C]5-aminolevulinic acid into uropor-phyrinogen III showed that isopropanol was metabolized into uroporphyrinogen III through acethl CoA and that 5-aminolevulinic acid was produced from L-glutamic acid and not via Shemin's pathway.
- 公益社団法人日本生物工学会の論文
- 1994-06-25
著者
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KAJIWARA MASAHIRO
Department of Medicinal Chemistry, Meiji Pharmaceutical University
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Kojima I
Mercian Corporation Central Research Laboratories
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Kojima Ichiro
Central Technical Research Laboratory Nippon Oil Company Ltd.
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Mizutani Minoru
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Mizutani Minoru
Department Of Internal Medicine Matsusaka Chuo General Hospital
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Kajiwara M
Meiji Pharmaceutical Univ. Tokyo Jpn
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Kajiwara Masahiro
Department Of Legal Medicine Kyorin University School Of Medicine
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MATSUDA REIKO
Department of Medicinal Chemistry, Meiji College of Pharmacy
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HARA KEN-ICHIRO
Department of Medicinal Chemistry, Meiji College of Pharmacy
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Matsuda Reiko
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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Hara Ken-ichiro
Department Of Medicinal Chemistry Meiji College Of Pharmacy
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